Wu Lei, He Yao, Jiang Bin, Liu Miao, Yang Shanshan, Wang Yiyan, Zeng Jing, Yao Yao, Wang Jianhua
Department of Epidemiology, Institute of Geriatrics, Chinese People's Liberation Army General Hospital State Key Laboratory of Kidney Disease, Chinese People's Liberation Army General Hospital Beijing Key Laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital Department of Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China.
Medicine (Baltimore). 2017 May;96(21):e6996. doi: 10.1097/MD.0000000000006996.
Few epidemiological studies have examined the association between serum aminotransferase levels and hypertension, and have yielded inconsistent results.A cross-sectional study was performed in a Chinese rural elderly population. A total of 2174 participants with normal range of aminotransferase levels and without excessive drinking were included in the present study. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured on fasting morning serum samples using the Kinetic method. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or receiving treatment for hypertension. Multiple logistic regression was used to estimate the association between gender-specific aminotransferase levels and hypertension.Increased serum ALT but not AST level was positively associated with hypertension. After adjusting for potential confounding variables, the association of hypertension and ALT level was only significant in women: for each 1 IU/L elevation of ALT level, the adjusted odds ratio (OR), and corresponding 95% confidence interval (CI) of hypertension was 1.04 (1.01, 1.07); the ORs of hypertension increased across tertiles of ALT, and the ORs (95% CIs) were 1.00, 1.17 (0.85, 1.60), and 1.63 (1.15, 2.31 (P value for trend = .021). Furthermore, the association was only significant in central obesity women or nondrinking women.ALT level was significantly associated with hypertension only in women in a Chinese rural elderly population. Further studies are warranted to explore the possible gender-related association and to extend them to different populations.
很少有流行病学研究考察血清转氨酶水平与高血压之间的关联，且结果并不一致。在中国农村老年人群中开展了一项横断面研究。本研究共纳入2174名转氨酶水平在正常范围且无过度饮酒的参与者。采用动力学法在空腹晨血清样本中检测丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平。高血压定义为收缩压≥140 mmHg和/或舒张压≥90 mmHg和/或接受高血压治疗。采用多因素logistic回归估计特定性别转氨酶水平与高血压之间的关联。血清ALT水平升高而非AST水平升高与高血压呈正相关。在调整潜在混杂变量后，高血压与ALT水平的关联仅在女性中显著：ALT水平每升高1 IU/L，高血压的校正比值比（OR）及相应的95%置信区间（CI）为1.04（1.01, 1.07）；高血压的OR值随ALT三分位数升高而增加，OR值（95%CI）分别为1.00、1.17（0.85, 1.60）和1.63（1.15, 2.31）（趋势P值 = 0.021）。此外，该关联仅在中心性肥胖女性或不饮酒女性中显著。在我国农村老年女性人群中，ALT水平仅与高血压显著相关。有必要进一步研究以探索可能的性别相关关联并将其扩展至不同人群。
