微小RNA在糖尿病中的作用。
Role of microRNAs in diabetes.
作者信息
Tang Xiaoqing, Tang Guiliang, Ozcan Sabire
机构信息
Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, 741 South Limestone, Lexington, KY 40536, USA.
出版信息
Biochim Biophys Acta. 2008 Nov;1779(11):697-701. doi: 10.1016/j.bbagrm.2008.06.010. Epub 2008 Jul 4.
Abstract
Diabetes is one of the most common chronic diseases in the world. Multiple and complex factors including various genetic and physiological changes can lead to type 1 and type 2 diabetes. However, the major mechanisms underlying the pathogenesis of diabetes remain obscure. With the recent discovery of microRNAs (miRNAs), these small ribonucleotides have been implicated as new players in the pathogenesis of diabetes and diabetes-associated complications. MiRNAs have been shown to regulate insulin production, insulin secretion, and insulin action. This review summarizes the recent progress in the cutting-edge research of miRNAs involved in diabetes and diabetes related complications.
摘要
糖尿病是世界上最常见的慢性病之一。多种复杂因素，包括各种基因和生理变化，可导致1型和2型糖尿病。然而，糖尿病发病机制的主要原因仍不清楚。随着最近微小RNA（miRNA）的发现，这些小核糖核苷酸被认为是糖尿病及其相关并发症发病机制中的新因素。已经证明，miRNA可调节胰岛素的产生、分泌及作用。本文综述了miRNA在糖尿病及其相关并发症前沿研究中的最新进展。
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