Department of Chemical Engineering, Northeastern University, Boston, Massachusetts.
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Biomed Mater Res A. 2017 Sep;105(9):2616-2621. doi: 10.1002/jbm.a.36119. Epub 2017 Jun 21.
Gold nanoparticles have been of great interest because of their unique optical properties, facile synthesis and conjugation. Among various shapes of gold nanoparticles, gold nanorods have been widely studied. They can be conjugated with different molecules for biomedical applications, such as tumor imaging and therapy. However, few researchers have studied the antitumor properties of bare gold nanorods. In this study, unfunctionalized gold nanorods were synthesized and tested on breast tumor cells. Results showed that the aspect ratio of gold nanorods could be easily influenced by both reaction time and the amount of silver nitrate in the growth solution. A new growth process is proposed here based on the UV-Vis spectra and TEM images of gold nanorods at different reaction times. More importantly, cell studies showed that within a certain concentration range, the gold nanorods can selectively kill tumor cells while having limited or little influence on healthy mammalian (dermal fibroblast) cells. Thus, this study shows promise for the use of bare gold nanorods for further study alone or in combination with photothermal treatment. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2616-2621, 2017.
金纳米粒子因其独特的光学性质、易于合成和缀合而受到广泛关注。在各种形状的金纳米粒子中，金纳米棒得到了广泛的研究。它们可以与不同的分子结合，用于生物医学应用，如肿瘤成像和治疗。然而，很少有研究人员研究过裸露的金纳米棒的抗肿瘤特性。在这项研究中，合成了未功能化的金纳米棒，并在乳腺癌细胞上进行了测试。结果表明，金纳米棒的纵横比很容易受到反应时间和生长溶液中硝酸银含量的影响。根据金纳米棒在不同反应时间的紫外-可见光谱和 TEM 图像，提出了一种新的生长过程。更重要的是，细胞研究表明，在一定浓度范围内，金纳米棒可以选择性地杀死肿瘤细胞，而对健康的哺乳动物（真皮成纤维细胞）细胞的影响有限或很小。因此，这项研究表明，裸露的金纳米棒具有很大的应用潜力，可以单独使用或与光热治疗联合使用。© 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2616-2621, 2017.
