Coastal Ear Nose and Throat, Neptune, NJ.
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Spain.
Int Forum Allergy Rhinol. 2017 Jul;7(7):645-651. doi: 10.1002/alr.21929. Epub 2017 May 25.
The effect of animal dander exposure on allergic sensitization may be age-dependent. A comparison between the association of the levels of exposure to pet allergen with rhinitis symptoms and allergic sensitization in children and adults is yet to be performed in the U.S.
Cross-sectional study of 3034 adults (age, 20 to 85 years) and 2104 children (age, 6 to 19 years) in the National Health and Nutrition Examination Survey, 2005-2006. Samples of household dust were collected to measure the amounts of indoor allergens in the participants' homes. Self-reported rhinitis was based on symptoms during the past 12 months, and allergen sensitization was defined as a positive response to any of the 19 specific immunoglobulin E (IgE) antigens tested.
Higher levels of exposure to dog dander were associated with a higher prevalence of any allergic sensitization in adults (prevalence ratio [PR] 1.19; 95% confidence interval [CI], 1.01 to 1.39), but a lower prevalence in children (PR 0.84; 95% CI, 0.73 to 0.096), p-interaction by age group 0.02. Cat exposure was associated with an increased prevalence of rhinitis symptoms in adults (PR for the 3rd vs lowest tertile of cat dander concentrations: 1.14; 95% CI, 1.05 to 1.23) but not in children (PR for the 3rd vs lowest tertile of cat dander IgE concentrations: 0.86; 95% CI, 0.70 to 1.07), p-interaction 0.01.
Allergic sensitization and symptomatic response to pet dander exposure may vary based on age. Further studies are necessary to assess the mechanisms for these apparent differences.
动物皮屑暴露对过敏致敏的影响可能具有年龄依赖性。在美国，还需要比较儿童和成人暴露于宠物过敏原水平与鼻炎症状和过敏致敏之间的关联。
这是一项横断面研究，纳入了 2005-2006 年美国国家健康和营养调查中的 3034 名成年人（年龄 20-85 岁）和 2104 名儿童（年龄 6-19 岁）。采集家庭灰尘样本以测量参与者家中室内过敏原的含量。自我报告的鼻炎基于过去 12 个月的症状，过敏致敏定义为对 19 种特定免疫球蛋白 E（IgE）抗原中的任何一种呈阳性反应。
狗皮屑暴露水平较高与成年人中任何过敏致敏的患病率较高相关（比值比 [PR] 1.19；95%置信区间 [CI]，1.01 至 1.39），但在儿童中较低（PR 0.84；95% CI，0.73 至 0.096），p 值为年龄组之间的交互作用 0.02。猫的暴露与成年人鼻炎症状的患病率增加相关（第 3 组与猫皮屑浓度最低 3 组相比：1.14；95% CI，1.05 至 1.23），但在儿童中没有相关性（第 3 组与猫皮屑 IgE 浓度最低 3 组相比：0.86；95% CI，0.70 至 1.07），p 值为交互作用 0.01。
过敏致敏和对宠物皮屑暴露的症状反应可能因年龄而异。需要进一步研究来评估这些明显差异的机制。
