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转移性多形性腺瘤病例报告及文献综述

Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature.

作者信息

Alshagroud Rana, Kamoh Amandip, Popat Saurin R, Brandwein-Weber Margaret, Aguirre Alfredo

机构信息

Advanced Oral and Maxillofacial Pathology Program, Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Department of Oral and Maxillofacial Surgery School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

出版信息

Head Neck Pathol. 2017 Dec;11(4):487-493. doi: 10.1007/s12105-017-0815-0. Epub 2017 May 25.

DOI:10.1007/s12105-017-0815-0
PMID:28547732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5677069/
Abstract

Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.

摘要

多形性腺瘤(PA)是迄今为止最常见的涎腺肿瘤。众所周知,PA可发生恶变。然而,在罕见情况下,它可在保持良性表型的同时发生转移。转移性多形性腺瘤(MPA)是一种极其罕见的肿瘤。在此,我们报告一例累及下颌骨的罕见MPA,其之前存在下颌下腺多形性腺瘤。

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本文引用的文献

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Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts.一致的PLAG1和HMGA2异常可将多形性腺瘤癌变与其原发性对应物区分开来。
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