转移性多形性腺瘤病例报告及文献综述
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature.
作者信息
Alshagroud Rana, Kamoh Amandip, Popat Saurin R, Brandwein-Weber Margaret, Aguirre Alfredo
机构信息
Advanced Oral and Maxillofacial Pathology Program, Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Department of Oral and Maxillofacial Surgery School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.
出版信息
Head Neck Pathol. 2017 Dec;11(4):487-493. doi: 10.1007/s12105-017-0815-0. Epub 2017 May 25.
Abstract
Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.
摘要
多形性腺瘤（PA）是迄今为止最常见的涎腺肿瘤。众所周知，PA可发生恶变。然而，在罕见情况下，它可在保持良性表型的同时发生转移。转移性多形性腺瘤（MPA）是一种极其罕见的肿瘤。在此，我们报告一例累及下颌骨的罕见MPA，其之前存在下颌下腺多形性腺瘤。
相似文献
1
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature.转移性多形性腺瘤病例报告及文献综述
Head Neck Pathol. 2017 Dec;11(4):487-493. doi: 10.1007/s12105-017-0815-0. Epub 2017 May 25.
2
Metastasizing pleomorphic adenoma of the salivary gland.涎腺转移性多形性腺瘤
Arch Pathol Lab Med. 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS.
3
Metastasising Pleomorphic Salivary Adenoma: A Rare Case Report of a Massive Untreated Minor Salivary Gland Pleomorphic Adenoma with Concurrent Ipsilateral Cervical Node Metastases.转移性多形性腺瘤：一例罕见的未治疗的巨大小涎腺多形性腺瘤并发同侧颈淋巴结转移病例报告
Head Neck Pathol. 2019 Sep;13(3):500-506. doi: 10.1007/s12105-018-0920-8. Epub 2018 May 3.
4
An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.包膜内癌型多形性腺瘤伴肺转移，转移灶中仅含良性成分：转移型多形性腺瘤与癌型多形性腺瘤之间存在连续性的组织学证据。
Pathol Res Pract. 2010 Jul 15;206(7):480-3. doi: 10.1016/j.prp.2009.07.008. Epub 2009 Aug 7.
5
Metastasizing pleomorphic adenoma: a report of three cases.转移性多形性腺瘤：三例报告
Eur J Surg Oncol. 1998 Oct;24(5):452-5. doi: 10.1016/s0748-7983(98)92651-8.
6
Multiple pulmonary metastases from benign pleomorphic adenoma.良性多形性腺瘤的多发性肺转移
Asian Cardiovasc Thorac Ann. 2008 Jan;16(1):62-4. doi: 10.1177/021849230801600116.
7
[Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].[大唾液腺多形性腺瘤癌变——临床病理综述]
Otolaryngol Pol. 2007;61(5):687-93. doi: 10.1016/S0030-6657(07)70507-3.
8
'Metastasizing pleomorphic salivary adenoma' should now be considered a low-grade malignancy with a lethal potential.“转移性多形性腺瘤”现在应被视为具有致命潜能的低级别恶性肿瘤。
Curr Opin Otolaryngol Head Neck Surg. 2005 Apr;13(2):123-6. doi: 10.1097/01.moo.0000153450.87288.2a.
9
A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.1例腮腺多形性腺瘤转移至纵隔淋巴结。
Am J Otolaryngol. 2007 Mar-Apr;28(2):130-3. doi: 10.1016/j.amjoto.2006.07.002.
10
Metastasizing Pleomorphic Adenoma: Recurrent PLAG1/HMGA2 Rearrangements and Identification of a Novel HMGA2-TMTC2 Fusion.转移性多形性腺瘤：PLAG1/HMGA2 重排的复发和新型 HMGA2-TMTC2 融合的鉴定。
Am J Surg Pathol. 2019 Aug;43(8):1145-1151. doi: 10.1097/PAS.0000000000001280.
引用本文的文献
1
Bilateral synchronous salivary gland tumors: report of three cases.双侧同步性唾液腺肿瘤：三例报告
Diagn Pathol. 2025 Jun 13;20(1):74. doi: 10.1186/s13000-025-01672-9.
2
Novel Detection of Pleomorphic Adenomas via Analysis of Ga-DOTATOC PET/CT Imaging.通过分析镓- DOTATOC PET/CT成像对多形性腺瘤进行新型检测
Cancers (Basel). 2024 Jul 23;16(15):2624. doi: 10.3390/cancers16152624.
3
A case of initially metastasizing pleomorphic adenoma of parotid gland.一例原发性转移性腮腺多形性腺瘤。
Rare Tumors. 2022 Oct 3;14:20363613221130155. doi: 10.1177/20363613221130155. eCollection 2022.
4
Synchronous Ipsilateral Pleomorphic Adenomas of Parotid and Submandibular Glands: An Unusual Finding.腮腺和下颌下腺同侧同步多形性腺瘤：一项罕见发现。
Case Rep Otolaryngol. 2020 Dec 28;2020:8887867. doi: 10.1155/2020/8887867. eCollection 2020.
5
Synchronous Parotid and Homolateral Submandibular Gland Pleomorphic Adenoma.同步性腮腺和同侧下颌下腺多形性腺瘤
Iran J Otorhinolaryngol. 2019 May;31(104):185-190.
6
Metastasizing Pleomporphic Adenoma - Case reports and review of literature.转移性多形性腺瘤——病例报告及文献综述
South Asian J Cancer. 2019 Apr-Jun;8(2):126. doi: 10.4103/sajc.sajc_19_19.
7
Metastasising Pleomorphic Salivary Adenoma: A Rare Case Report of a Massive Untreated Minor Salivary Gland Pleomorphic Adenoma with Concurrent Ipsilateral Cervical Node Metastases.转移性多形性腺瘤：一例罕见的未治疗的巨大小涎腺多形性腺瘤并发同侧颈淋巴结转移病例报告
Head Neck Pathol. 2019 Sep;13(3):500-506. doi: 10.1007/s12105-018-0920-8. Epub 2018 May 3.
本文引用的文献
1
Metastasizing pleomorphic adenoma in cavernous sinus: letter to the editor.海绵窦转移性多形性腺瘤：致编辑的信
Acta Neurochir (Wien). 2016 Apr;158(4):647-648. doi: 10.1007/s00701-016-2751-2. Epub 2016 Feb 26.
2
Benign metastasizing pleomorphic adenoma in liver mimicking synchronic metastatic disease from colorectal cancer: a case report with emphasis on imaging findings.肝脏良性转移性多形性腺瘤酷似结直肠癌同期转移性疾病：1例报告并着重分析影像学表现
Acta Radiol Open. 2015 Aug 7;4(8):2058460115594199. doi: 10.1177/2058460115594199. eCollection 2015 Aug.
3
Metastasising pleomorphic adenoma: Systematic review.转移性多形性腺瘤：系统评价。
Int J Surg. 2015 Jul;19:137-45. doi: 10.1016/j.ijsu.2015.04.084. Epub 2015 May 6.
4
Intraosseous pleomorphic adenoma of the mandible.下颌骨骨内多形性腺瘤
Iran J Radiol. 2015 Jan 1;12(1):e6921. doi: 10.5812/iranjradiol.6921. eCollection 2015 Jan.
5
Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts.一致的PLAG1和HMGA2异常可将多形性腺瘤癌变与其原发性对应物区分开来。
Hum Pathol. 2015 Jan;46(1):26-33. doi: 10.1016/j.humpath.2014.08.017. Epub 2014 Sep 7.
6
Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.转移性“良性”多形性腺瘤：一则典型病例报告及文献综述
J Craniomaxillofac Surg. 2014 Dec;42(8):1562-5. doi: 10.1016/j.jcms.2014.01.014. Epub 2014 Jan 14.
7
A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate.上颌骨转移性多形性腺瘤病例，在硬腭多形性腺瘤初次切除后 20 年出现。
Pathol Int. 2013 Sep;63(9):463-8. doi: 10.1111/pin.12087. Epub 2013 Aug 28.
8
Metastasizing pleomorphic adenoma presents intraorally: a case report and review of the literature.转移性多形性腺瘤的口腔内表现：一例报告并文献复习
J Oral Maxillofac Surg. 2012 Oct;70(10):e531-40. doi: 10.1016/j.joms.2012.06.185.
9
Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature.头颈部大型涎腺多形性腺瘤：10 年经验及文献回顾。
Eur Arch Otorhinolaryngol. 2011 Jul;268(7):1035-40. doi: 10.1007/s00405-010-1437-2. Epub 2010 Dec 1.
Zotero 插件