School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland 4072, Australia.
GSK Vaccines Institute for Global Health S.r.l., 53100, Siena, Italy.
Trends Microbiol. 2017 Sep;25(9):729-740. doi: 10.1016/j.tim.2017.04.006. Epub 2017 May 24.
Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple 'omic' technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.
尿路致病性大肠杆菌（UPEC）是对全球人类健康具有重要意义的病原体，与迅速增加的抗生素耐药性密切相关。UPEC 是尿路感染（UTI）的主要原因，这种疾病涉及与宿主相互作用时的细胞外和细胞内生活方式的复杂发病途径。包括基因组学、转录组学、蛋白质组学和代谢组学在内的多种“组学”技术的应用，为我们了解 UPEC 生物学提供了巨大的知识。在这里，我们概述了这一进展，并提出了利用这些令人兴奋的前沿技术来充分理解感染背景下 UPEC 发病机制的未来发展方向。
