Signes-Pastor Antonio J, Carey Manus, Vioque Jesus, Navarrete-Muñoz Eva M, Rodríguez-Dehli Cristina, Tardón Adonina, Begoña-Zubero Miren, Santa-Marina Loreto, Vrijheid Martine, Casas Maribel, Llop Sabrina, Gonzalez-Palacios Sandra, Meharg Andrew A
Institute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast, BT9 5BN Northern Ireland, UK.
Universidad Miguel Hernández, Avenida de Alicante KM 87, 03550 Sant Joan d'Alacant, Spain.
Expo Health. 2017;9(2):105-111. doi: 10.1007/s12403-016-0225-7. Epub 2016 Aug 12.
Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine-AsB), 3.97 μg/l (dimethylarsinic acid-DMA), 0.44 μg/l (monomethylarsonic acid-MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.
无机砷（i-As）是一种无阈值的人类致癌物，与多种不良健康后果相关。孕妇、婴儿和儿童接触i-As尤其令人担忧，因为他们特别容易受到i-As不良健康影响，而且子宫内和生命早期接触，即使是低至中等水平的i-As，也可能在整个生命周期产生显著影响。离子色谱-质谱检测（IC-ICP-MS）用于分析西班牙不同地区（包括阿斯图里亚斯、吉普斯夸、萨巴德尔和巴伦西亚）砷暴露水平相对较低的4岁儿童样本中的尿砷形态，作为一种暴露生物标志物。还对孕期（孕早期）采集的样本以及巴伦西亚7岁儿童的样本进行了尿中砷代谢物谱分析。在4岁儿童中发现的主要砷形态的中位数分别为9.71μg/l（砷甜菜碱-AsB）、3.97μg/l（二甲基砷酸-DMA）、0.44μg/l（一甲基砷酸-MMA）和0.35μg/l（i-As）。4岁儿童中，根据研究地区，尿中AsB、MMA和i-As存在统计学显著差异，孕妇及其子女的尿中DMA也存在差异。计算了尿砷代谢物之间的斯皮尔曼相关系数，总体上观察到将i-As甲基化为MMA的甲基化能力较强。
