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Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C.

作者信息

Mayer B J, Hamaguchi M, Hanafusa H

机构信息

Rockefeller University, New York, New York 10021.

出版信息

Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:907-14. doi: 10.1101/sqb.1988.053.01.104.

DOI:10.1101/sqb.1988.053.01.104
PMID:2855503
Abstract
摘要

相似文献

1
Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C.p47gag-crk的特性,一种与蛋白酪氨酸激酶和磷脂酶C的假定调节结构域具有序列相似性的新型癌基因产物。
Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:907-14. doi: 10.1101/sqb.1988.053.01.104.
2
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.v-crk癌基因产物与含磷酸酪氨酸的蛋白质及蛋白激酶活性的关联。
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2638-42. doi: 10.1073/pnas.87.7.2638.
3
Purification and characterization of P47gag-crk expressed in insect cells.在昆虫细胞中表达的P47gag-crk的纯化与特性分析
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4
Cell transformation by an oncogene that regulates protein kinases.
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5
Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.包含磷脂酰肌醇特异性磷脂酶C-γ和Src的SH2/SH3区域的v-Crk嵌合体的生物学和生化活性
J Virol. 1992 Jan;66(1):115-21. doi: 10.1128/JVI.66.1.115-121.1992.
6
A novel viral oncogene with structural similarity to phospholipase C.一种与磷脂酶C结构相似的新型病毒癌基因。
Nature. 1988 Mar 17;332(6161):272-5. doi: 10.1038/332272a0.
7
Most of the substrates of oncogenic viral tyrosine protein kinases can be phosphorylated by cellular tyrosine protein kinases in normal cells.致癌病毒酪氨酸蛋白激酶的大多数底物在正常细胞中可被细胞酪氨酸蛋白激酶磷酸化。
Oncogene Res. 1988 Sep;3(2):105-15.
8
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.在细胞质蛋白酪氨酸激酶中保守的一个非催化结构域可改变藤浪肉瘤病毒P130gag-fps的激酶功能和转化活性。
Mol Cell Biol. 1986 Dec;6(12):4396-408. doi: 10.1128/mcb.6.12.4396-4408.1986.
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Modification of carboxyl-terminal region is the cause of activation of the src gene in avian sarcoma virus S2.羧基末端区域的修饰是禽肉瘤病毒S2中src基因激活的原因。
Jpn J Cancer Res. 1986 Jul;77(7):611-4.
10
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins.转化蛋白P47gag-crk与多种含磷酸酪氨酸的蛋白的结合。
Science. 1990 Jun 22;248(4962):1537-9. doi: 10.1126/science.1694307.

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Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).成纤维细胞生长需要激酶CT10调节因子(Crk)和类Crk(CrkL)。
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Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis.
KRAS/PAK1/Crk通路在非小细胞肺癌发生中的意义。
BMC Cancer. 2015 May 9;15:381. doi: 10.1186/s12885-015-1360-4.
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Contribution of Crk adaptor proteins to host cell and bacteria interactions.Crk衔接蛋白在宿主细胞与细菌相互作用中的作用。
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Crk adaptors negatively regulate actin polymerization in pedestals formed by enteropathogenic Escherichia coli (EPEC) by binding to Tir effector.Crk衔接蛋白通过与Tir效应蛋白结合,对肠致病性大肠杆菌(EPEC)形成的菌毛中的肌动蛋白聚合起负调控作用。
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The adaptor protein Crk in immune response.衔接蛋白 Crk 在免疫反应中的作用。
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The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.衔接蛋白 CRK 是内质网应激的促凋亡转导子。
Nat Cell Biol. 2011 Dec 18;14(1):87-92. doi: 10.1038/ncb2395.
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Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo.Nck2 促进人黑色素瘤细胞在体外的增殖、迁移和侵袭以及原代黑色素瘤衍生的肿瘤在体内的生长。
BMC Cancer. 2011 Oct 12;11:443. doi: 10.1186/1471-2407-11-443.
10
Cell signaling in space and time: where proteins come together and when they're apart.细胞信号转导的时空机制:蛋白质的聚合与解离。
Science. 2009 Nov 27;326(5957):1220-4. doi: 10.1126/science.1175668.