Chondronikola Maria, Porter Craig, Malagaris Ioannis, Nella Aikaterini A, Sidossis Labros S
Metabolism UnitShriners Hospitals for Children-Galveston, Galveston, Texas, USA.
Division of Rehabilitation SciencesDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, USA.
Eur J Endocrinol. 2017 Jul;177(1):33-40. doi: 10.1530/EJE-16-0958.
Brown adipose tissue (BAT) has been proposed as a potential therapeutic target against obesity and its related metabolic conditions. Data from studies in rodents support a cross talk between BAT and other distal tissues. The relation between BAT and peptide hormones secreted from the gastrointestinal system (GI) and involved in appetite regulation is not known in humans.
We studied 18 men during thermoneutral conditions and mild non-shivering cold exposure (CE).
2-Deoxy-2-(F)fluoro-d-glucose positron emission tomography-computed tomography scans were conducted after mild cold to measure BAT volume. Fasting serum concentration of GI-secreted peptides and peptides involved in appetite regulation were measured during thermoneutral conditions and mild CE.
During thermoneutral conditions, BAT volume was associated with lower serum concentration of leptin ( = 0.006), gastric inhibitory polypeptide ( = 0.016) and glucagon ( = 0.048) after adjusting for age and body fat percent. CE significantly decreased serum leptin ( = 0.004) and glucagon concentration ( = 0.020), while cold-induced BAT activation was significantly associated with lower serum ghrelin concentration ( = 0.029).
BAT is associated with systemic concentrations of GI-secreted peptides and peptides involved in appetite regulation, suggesting a potential cross talk between BAT and the enteropancreatic axis. Further studies are needed to elucidate the potential link of BAT with the postprandial levels of appetite-regulating peptides and the putative role of BAT in appetite regulation in humans.
棕色脂肪组织（BAT）已被提出作为对抗肥胖及其相关代谢状况的潜在治疗靶点。啮齿动物研究数据支持BAT与其他远端组织之间存在相互作用。在人类中，BAT与胃肠道系统（GI）分泌的、参与食欲调节的肽类激素之间的关系尚不清楚。
我们研究了18名男性在热中性条件和轻度非寒战冷暴露（CE）期间的情况。
轻度冷暴露后进行2-脱氧-2-（F）氟-D-葡萄糖正电子发射断层扫描-计算机断层扫描以测量BAT体积。在热中性条件和轻度CE期间测量空腹血清中GI分泌的肽类和参与食欲调节的肽类浓度。
在热中性条件下，调整年龄和体脂百分比后，BAT体积与较低的血清瘦素浓度（P = 0.006）、胃抑制多肽浓度（P = 0.016）和胰高血糖素浓度（P = 0.048）相关。CE显著降低血清瘦素（P = 0.004）和胰高血糖素浓度（P = 0.020），而冷诱导的BAT激活与较低的血清胃饥饿素浓度显著相关（P = 0.029）。
BAT与GI分泌的肽类和参与食欲调节的肽类的全身浓度相关，提示BAT与肠胰轴之间可能存在相互作用。需要进一步研究以阐明BAT与食欲调节肽餐后水平的潜在联系以及BAT在人类食欲调节中的假定作用。
