Kar Usha P, Dey Himani, Rahaman Abdur
School of Biological Sciences, National Institute of Science Education and Research- Bhubaneswar, HBNI, 752050, Odisha, India.
J Biosci. 2017 Jun;42(2):333-344. doi: 10.1007/s12038-017-9680-y.
Dynamin superfamily proteins comprising classical dynamins and related proteins are membrane remodelling agents involved in several biological processes such as endocytosis, maintenance of organelle morphology and viral resistance. These large GTPases couple GTP hydrolysis with membrane alterations such as fission, fusion or tubulation by undergoing repeated cycles of self-assembly/disassembly. The functions of these proteins are regulated by various post-translational modifications that affect their GTPase activity, multimerization or membrane association. Recently, several reports have demonstrated variety of such modifications providing a better understanding of the mechanisms by which dynamin proteins influence cellular responses to physiological and environmental cues. In this review, we discuss major post-translational modifications along with their roles in the mechanism of dynamin functions and implications in various cellular processes.
由经典发动蛋白和相关蛋白组成的发动蛋白超家族蛋白是参与多种生物学过程的膜重塑因子，如内吞作用、细胞器形态维持和病毒抗性。这些大型GTP酶通过经历反复的自组装/解聚循环，将GTP水解与膜改变（如裂变、融合或微管形成）偶联起来。这些蛋白质的功能受多种翻译后修饰的调节，这些修饰会影响它们的GTP酶活性、多聚化或膜结合。最近，一些报告已经证明了多种此类修饰，这有助于更好地理解发动蛋白影响细胞对生理和环境信号反应的机制。在这篇综述中，我们讨论了主要的翻译后修饰及其在发动蛋白功能机制中的作用以及在各种细胞过程中的意义。
