• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

.的水提取物的抗炎和抗胰岛素抵抗活性

Anti-inflammatory and anti-insulin resistance activities of aqueous extract from .

作者信息

Budluang Phatcharaporn, Pitchakarn Pornsiri, Ting Pisamai, Temviriyanukul Piya, Wongnoppawich Ariyaphong, Imsumran Arisa

机构信息

Department of Biochemistry Faculty of Medicine Chiang Mai University Meung Chiang Mai Thailand.

Food and Nutritional Toxicology Unit Institute of Nutrition Mahidol University Salaya Nakhon Pathom Thailand.

出版信息

Food Sci Nutr. 2016 Aug 26;5(3):486-496. doi: 10.1002/fsn3.416. eCollection 2017 May.

DOI:10.1002/fsn3.416
PMID:28572933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5449198/
Abstract

This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases.

摘要

本研究调查了水提取物（ABE）的生物活性，包括抗氧化应激、抗炎和抗胰岛素抵抗。结果表明，ABE具有以剂量依赖性方式清除DPPH和ABTS自由基的能力。此外，ABE通过抑制一氧化氮合酶（iNOS）的mRNA和蛋白质表达，显著降低了脂多糖（LPS）处理的RAW 264.7细胞中一氧化氮（NO）的产生。LPS诱导的环氧化酶-2（COX-2）和白细胞介素1β（IL-1β）的mRNA表达受到ABE的抑制。此外，ABE具有抗胰岛素抵抗活性，因为它显著改善了肿瘤坏死因子（TNF）-α处理的3T3-L1脂肪细胞中的葡萄糖摄取。此外，浓度高达200μg/mL的ABE对人外周血单个核细胞（PBMCs）无毒，也不诱导突变。最后，我们的研究结果表明，ABE有潜力用作抗炎、抗胰岛素抵抗药物或预防慢性病的食品补充剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/9d2be86cf064/FSN3-5-486-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/cfb14881b20a/FSN3-5-486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/202a97aefe32/FSN3-5-486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/efed487ff113/FSN3-5-486-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/9d2be86cf064/FSN3-5-486-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/cfb14881b20a/FSN3-5-486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/202a97aefe32/FSN3-5-486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/efed487ff113/FSN3-5-486-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3e/5449198/9d2be86cf064/FSN3-5-486-g004.jpg

相似文献

1
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from ..的水提取物的抗炎和抗胰岛素抵抗活性
Food Sci Nutr. 2016 Aug 26;5(3):486-496. doi: 10.1002/fsn3.416. eCollection 2017 May.
2
Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7 cells.基于生物测定的研究：拳参正丁醇提取物对 RAW 264.7 细胞的抗炎作用。
J Ethnopharmacol. 2021 Nov 15;280:114452. doi: 10.1016/j.jep.2021.114452. Epub 2021 Jul 24.
3
The Toxicological Assessment of Ethanolic-Extract-Synthesized Selenium Nanoparticles Using Cell Culture, Bacteria, and as Suitable Models.使用细胞培养、细菌作为合适模型对乙醇提取物合成的硒纳米颗粒进行毒理学评估。
Nanomaterials (Basel). 2023 Oct 22;13(20):2804. doi: 10.3390/nano13202804.
4
Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using Extract as a Potential Novel Functional Ingredient.利用[提取物]作为潜在新型功能成分稳定纳米硒的抗氧化和抗炎活性。
Nutrients. 2023 Feb 17;15(4):1018. doi: 10.3390/nu15041018.
5
Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima.水飞蓟素的抗氧化和抗炎活性。
J Ethnopharmacol. 2013 May 20;147(2):395-405. doi: 10.1016/j.jep.2013.03.025. Epub 2013 Mar 15.
6
Biomolecular evidence of anti-inflammatory effects by Clematis mandshurica Ruprecht root extract in rodent cells.毛茛科Clematis mandshurica Ruprecht 根提取物在啮齿类细胞中的抗炎作用的生物分子证据。
J Ethnopharmacol. 2014 Sep 11;155(2):1141-55. doi: 10.1016/j.jep.2014.06.048. Epub 2014 Jun 27.
7
Centella asiatica (L.) extract attenuates inflammation and improve insulin sensitivity in a coculture of lipopolysaccharide (LPS)-induced 3T3-L1 adipocytes and RAW 264.7 macrophages.积雪草提取物可减轻脂多糖（LPS）诱导的3T3-L1脂肪细胞与RAW 264.7巨噬细胞共培养体系中的炎症反应并改善胰岛素敏感性。
Drug Discov Ther. 2019;13(5):261-267. doi: 10.5582/ddt.2019.01052.
8
Antioxidative and anti-inflammatory effect of on RAW 264.7 macrophage cells.[物质名称]对RAW 264.7巨噬细胞的抗氧化和抗炎作用。 （注：原文中“of”后面缺少具体物质，这里补充了“[物质名称]”使句子完整通顺）
J Exerc Rehabil. 2019 Feb 25;15(1):2-7. doi: 10.12965/jer.1938010.005. eCollection 2019 Feb.
9
Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages.三七花提取物通过阻断小鼠巨噬细胞中的NF-κB信号通路减轻脂多糖诱导的炎症反应。
J Ethnopharmacol. 2009 Mar 18;122(2):313-9. doi: 10.1016/j.jep.2008.12.024. Epub 2008 Dec 27.
10
Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis.刺玫果提取物对大鼠内毒素诱导性葡萄膜炎的抗炎作用。
Invest Ophthalmol Vis Sci. 2005 Jan;46(1):275-81. doi: 10.1167/iovs.04-0715.

引用本文的文献

1
Extract Rescues Aging-Related Phenotypes in Susceptible to Oxidative Stress-Induced Senescence.提取物可挽救易受氧化应激诱导衰老影响的衰老相关表型。
Int J Mol Sci. 2025 Jun 13;26(12):5694. doi: 10.3390/ijms26125694.
2
Verification of the chromosome number using cytogenetics and estimation of genome size via flow cytometry and k-mer analyses for representative Anoectochilus roxburghii accessions.使用细胞遗传学方法验证染色体数目，并通过流式细胞术和k-mer分析估计代表性金线莲种质的基因组大小。
PLoS One. 2025 May 28;20(5):e0322457. doi: 10.1371/journal.pone.0322457. eCollection 2025.
3
Anti-Hyperglycemic Effects of Thai Herbal Medicines.

本文引用的文献

1
Antihyperglycemic activity of Anoectochilus roxburghii polysaccharose in diabetic mice induced by high-fat diet and streptozotocin.金线莲多糖对高脂饮食联合链脲佐菌素诱导的糖尿病小鼠的降血糖活性
J Ethnopharmacol. 2015 Apr 22;164:180-5. doi: 10.1016/j.jep.2015.01.050. Epub 2015 Feb 7.
2
Association between inflammatory markers and liver fat: The Multi-Ethnic Study of Atherosclerosis.炎症标志物与肝脏脂肪之间的关联：动脉粥样硬化多族裔研究
J Clin Exp Cardiolog. 2014;5. doi: 10.4172/2155-9880.1000344.
3
Extracts of Actinidia arguta stems inhibited LPS-induced inflammatory responses through nuclear factor-κB pathway in Raw 264.7 cells.
泰国草药的降血糖作用。
Plants (Basel). 2024 Oct 13;13(20):2862. doi: 10.3390/plants13202862.
4
Anti-Inflammatory, Cytotoxic, and Genotoxic Effects of Soybean Oligopeptides Conjugated with Mannose.与甘露糖结合的大豆寡肽的抗炎、细胞毒性和遗传毒性作用
Foods. 2024 Aug 16;13(16):2558. doi: 10.3390/foods13162558.
5
Anti-Inflammatory and Anti-Adipocyte Dysfunction Effects of Latex and Root Extracts.乳胶和根提取物的抗炎及抗脂肪细胞功能障碍作用
Pharmaceuticals (Basel). 2024 Feb 23;17(3):287. doi: 10.3390/ph17030287.
6
The Toxicological Assessment of Ethanolic-Extract-Synthesized Selenium Nanoparticles Using Cell Culture, Bacteria, and as Suitable Models.使用细胞培养、细菌作为合适模型对乙醇提取物合成的硒纳米颗粒进行毒理学评估。
Nanomaterials (Basel). 2023 Oct 22;13(20):2804. doi: 10.3390/nano13202804.
7
An Evaluation of the Anti-Inflammatory Effects of a Thai Traditional Polyherbal Recipe TPDM6315 in LPS-Induced RAW264.7 Macrophages and TNF-α-Induced 3T3-L1 Adipocytes.泰国传统多草药配方TPDM6315对脂多糖诱导的RAW264.7巨噬细胞和肿瘤坏死因子-α诱导的3T3-L1脂肪细胞的抗炎作用评估。
Curr Issues Mol Biol. 2023 Jun 5;45(6):4891-4907. doi: 10.3390/cimb45060311.
8
Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using Extract as a Potential Novel Functional Ingredient.利用[提取物]作为潜在新型功能成分稳定纳米硒的抗氧化和抗炎活性。
Nutrients. 2023 Feb 17;15(4):1018. doi: 10.3390/nu15041018.
9
Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A.铁皮石斛提取物及其活性化合物金钗石斛苷对邻苯二甲酸丁基苄基酯和双酚 A 诱导的脂肪细胞分化的保护作用。
Sci Rep. 2023 Feb 20;13(1):2939. doi: 10.1038/s41598-023-30227-5.
10
Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders.人参皂苷对炎症和氧化应激诱导的疾病的治疗应用及药理特性研究进展。
Front Pharmacol. 2022 Oct 4;13:1009550. doi: 10.3389/fphar.2022.1009550. eCollection 2022.
软枣猕猴桃茎提取物通过核因子-κB途径抑制Raw 264.7细胞中脂多糖诱导的炎症反应。
Nutr Res. 2014 Nov;34(11):1008-16. doi: 10.1016/j.nutres.2014.08.019.
4
Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from Western Nepal.来自尼泊尔西部的八种药用植物的抗氧化活性及酚类和类黄酮含量。
J Tradit Chin Med. 2014 Oct;34(5):584-90. doi: 10.1016/s0254-6272(15)30067-4.
5
Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase.通过抑制 NF-κB 和 MAP 激酶来研究朝鲜悬钩子的抗炎作用。
Nutr Res Pract. 2014 Oct;8(5):501-8. doi: 10.4162/nrp.2014.8.5.501. Epub 2014 May 15.
6
Antioxidant capacities, phenolic profile and cytotoxic effects of saxicolous lichens from trans-Himalayan cold desert of Ladakh.拉达克跨喜马拉雅寒冷沙漠中石生地衣的抗氧化能力、酚类成分及细胞毒性作用
PLoS One. 2014 Jun 17;9(6):e98696. doi: 10.1371/journal.pone.0098696. eCollection 2014.
7
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.炎症作为肥胖、代谢综合征和 2 型糖尿病之间的联系。
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. Epub 2014 Apr 13.
8
Inflammatory markers in patients with rheumatoid arthritis.类风湿关节炎患者的炎症标志物。
Allergol Immunopathol (Madr). 2015 Jan-Feb;43(1):81-7. doi: 10.1016/j.aller.2013.11.003. Epub 2014 Mar 20.
9
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines.肥胖相关炎症和胰岛素抵抗中的脂肪组织：细胞、细胞因子和趋化因子。
ISRN Inflamm. 2013 Dec 22;2013:139239. doi: 10.1155/2013/139239.
10
Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression.羟钴胺素通过双相调节 NOS 的表达、蛋白和亚硝酸盐产物，从而发挥其在脓毒性休克中的保护作用：下游调节 COX-2、IL-1β、TNF-α、IL-6 和 HMGB1 的表达。
Mediators Inflamm. 2013;2013:741804. doi: 10.1155/2013/741804. Epub 2013 May 28.