Uversky Vladimir N
Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL, 33612, USA.
Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
Cell Mol Life Sci. 2017 Sep;74(17):3065-3067. doi: 10.1007/s00018-017-2554-5. Epub 2017 Jun 6.
The concept of protein intrinsic disorder persistently penetrates into all areas of modern protein science. It cannot be ignored anymore, and cannot be shrugged off, as it represents a vital feature (or, more correctly, a broad spectrum of important features), which, when added to and mixed with features arising from the well established protein structure-function paradigm, complete the picture of a functioning protein. The field of protein intrinsic disorder is very dynamic and fast developing. This Multi-Author Review represents a snapshot of this field by introducing some recent advances. Articles assembled in this Multi-Author Review introduce some of the new aspects of intrinsic disorder, outline some fascinating ideas related to the intrinsically disordered proteins, their structure, and functionality, and show challenges related to the analysis of proteins carrying intrinsic disorder.
蛋白质内在无序的概念持续渗透到现代蛋白质科学的各个领域。它再也不能被忽视，也不能被置之不理，因为它代表了一个至关重要的特征（或者更准确地说，是一系列广泛的重要特征），当与已确立的蛋白质结构 - 功能范式所产生的特征相加并混合时，就完善了功能性蛋白质的全貌。蛋白质内在无序领域非常活跃且发展迅速。这篇多作者综述通过介绍一些最新进展呈现了该领域的一个快照。本多作者综述中汇集的文章介绍了内在无序的一些新方面，概述了与内在无序蛋白质、其结构和功能相关的一些引人入胜的观点，并展示了与分析携带内在无序的蛋白质相关的挑战。
