Williams A O, Reveley M A, Kolakowska T, Ardern M, Mandelbrote B M
Br J Psychiatry. 1985 Mar;146:239-46. doi: 10.1192/bjp.146.3.239.
Computer tomography brain scans were carried out on 40 patients with schizophrenia or schizo-affective disorder of 2-20 years duration. Ventricular-brain ratio (VBR) was significantly greater than that of the control group. In six patients the VBR exceeded the control mean + 2 s.d. Among the 13 whose VBR was more than 1 s.d. above the control mean, none had schizo-affective disorder, all but one had chronic illness, and patients with negative symptoms and those with premorbid schizoid traits were over-represented. VBR was unrelated to medical history, age, duration of illness, or neuroleptic treatment. It was not associated with neurological 'soft' signs or cognitive deficit. Among chronic patients, clinical features showed no association with ventricular size. The findings suggest that large ventricles may be related to a sub-type of chronic schizophrenia rather than to its particular clinical features.
对40例病程为2至20年的精神分裂症或分裂情感性障碍患者进行了脑部计算机断层扫描。脑室-脑比率（VBR）显著高于对照组。6例患者的VBR超过对照组均值加2个标准差。在VBR高于对照组均值1个标准差以上的13例患者中，无人患有分裂情感性障碍，除1例之外均患有慢性病，且阴性症状患者和病前具有分裂样特质的患者比例过高。VBR与病史、年龄、病程或抗精神病药物治疗无关。它与神经系统“软”体征或认知缺陷无关。在慢性病患者中，临床特征与脑室大小无关。研究结果表明，较大的脑室可能与慢性精神分裂症的一种亚型有关，而非与其特定的临床特征有关。
