Kolakowska T, Williams A O, Jambor K, Ardern M
Br J Psychiatry. 1985 Apr;146:348-57. doi: 10.1192/bjp.146.4.348.
Fifty-six patients with RDC schizophrenia (42) or schizoaffective disorder (14), of two to 20 years' duration, were assessed for neurological 'soft' signs and cognitive impairment when in a stable condition--the 'outcome'. Neurological dysfunction (46% of 50 examined patients) was associated with a history of developmental abnormalities, but was unrelated to outcome, psychiatric symptoms, or treatment. Deficits in particular cognitive fields were related to two independent factors: overall severity of residual psychiatric disorder (outcome) and neurological dysfunction. There was no relationship between the size of the lateral brain ventricles on CT scan and either 'soft' signs or cognitive impairment. The findings do not provide evidence for an association between the presence of organic brain disorder (as indicated by the joint occurrence of neurological dysfunction and cognitive impairment) and either poor outcome or particular symptoms of schizophrenia.
56例患有精神分裂症（42例）或分裂情感性障碍（14例）、病程在2至20年的患者，在病情稳定时（即“结果”）接受了神经学“软”体征和认知障碍评估。神经功能障碍（在50例接受检查的患者中占46%）与发育异常史有关，但与结果、精神症状或治疗无关。特定认知领域的缺陷与两个独立因素有关：残留精神障碍的总体严重程度（结果）和神经功能障碍。CT扫描显示的侧脑室大小与“软”体征或认知障碍之间均无关联。这些发现并未为器质性脑疾病（由神经功能障碍和认知障碍共同表明）的存在与精神分裂症的不良结果或特定症状之间的关联提供证据。
