Tian Tian, Li Xukun, Hua Zhen, Ma Jianlin, Liu Zhihua, Chen Hongyan, Cui Zhumei
Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
These authors contributed equally to this article.
Discov Med. 2017 Apr;23(127):235-245.
S100A1 is a calcium-binding protein belonging to the family of S100 proteins, and is highly expressed in ovarian cancer. However, its role in ovarian cancer has not yet been fully elucidated. In this study, we examined S100A1 expression in ovarian cancer tissues and normal tissue controls and analyzed the correlation between S100A1 expression and clinicopathological parameters. We found that S100A1 expression was significantly upregulated in ovarian cancer tissues compared with fallopian and normal ovarian epithelium tissues and was significantly associated with lymph node metastasis and International Federation of Gynecology and Obstetrics (FIGO) stages and tumor grades. We then investigated the biological functions of S100A1 in ovarian cancer by cell proliferation, fluorescence-activated cell sorting (FACS), and migration and invasion assays. The results indicated that S100A1 enhanced the ovarian cancer cell proliferation and migration. Together, our findings demonstrated that S100A1 plays an important role in the malignancy of ovarian cancer, and serves as a useful marker for the detection of ovarian malignancy.
S100A1是一种属于S100蛋白家族的钙结合蛋白，在卵巢癌中高表达。然而，其在卵巢癌中的作用尚未完全阐明。在本研究中，我们检测了卵巢癌组织和正常组织对照中S100A1的表达，并分析了S100A1表达与临床病理参数之间的相关性。我们发现，与输卵管和正常卵巢上皮组织相比，卵巢癌组织中S100A1表达显著上调，且与淋巴结转移、国际妇产科联盟（FIGO）分期及肿瘤分级显著相关。然后，我们通过细胞增殖、荧光激活细胞分选（FACS）以及迁移和侵袭实验研究了S100A1在卵巢癌中的生物学功能。结果表明，S100A1增强了卵巢癌细胞的增殖和迁移能力。总之，我们的研究结果表明，S100A1在卵巢癌恶性进展中起重要作用，可作为检测卵巢恶性肿瘤的有用标志物。
