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感染媒介中的免疫、宿主生理学和行为。

Immunity, host physiology, and behaviour in infected vectors.

机构信息

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA; Odum School of Ecology, University of Georgia, 140 E. Green Street, Athens GA 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D.W. Brooks Drive, Athens GA 30602, USA; Center for the Ecology of Infectious Diseases, Odum School of Ecology, University of Georgia, 140 E. Green Street, Athens GA 30602, USA; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens GA 30602, USA; University of Georgia Riverbasin Center, University of Georgia,203 D.W. Brooks Drive, Athens, GA 30602, USA.

Department of Medical Microbiology and Immunology, University of California, Davis, USA.

出版信息

Curr Opin Insect Sci. 2017 Apr;20:28-33. doi: 10.1016/j.cois.2017.03.001. Epub 2017 Mar 15.

Abstract

When infection alters host behaviour such that the pathogen benefits, the behaviour is termed a manipulation. There are several examples of this fascinating phenomenon in many different systems. Vector-borne diseases are no exception. In some instances, as the term implies, pathogens directly interfere with host processes to control behaviour. However, host response to infection and host physiology are likely to play important roles in these phenotypes. We highlight the importance of considering host response and physiology from recent work on altered host-seeking in malaria parasite-infected mosquitoes and argue that this general approach will provide useful insights across vector-borne disease systems.

摘要

当感染改变宿主行为,使病原体受益时,这种行为就被称为操纵。在许多不同的系统中,都有这种迷人现象的例子。虫媒传染病也不例外。在某些情况下,正如术语所暗示的,病原体直接干扰宿主过程来控制行为。然而,宿主对感染的反应和宿主生理学可能在这些表型中发挥重要作用。我们从最近关于疟疾寄生虫感染蚊子改变宿主觅性的研究中强调了考虑宿主反应和生理学的重要性,并认为这种通用方法将为虫媒传染病系统提供有用的见解。

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