Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
Cell. 2017 Jun 15;169(7):1291-1302.e14. doi: 10.1016/j.cell.2017.05.023. Epub 2017 Jun 9.
The emergence of sensory-guided behavior depends on sensorimotor coupling during development. How sensorimotor experience shapes neural processing is unclear. Here, we show that the coupling between motor output and visual feedback is necessary for the functional development of visual processing in layer 2/3 (L2/3) of primary visual cortex (V1) of the mouse. Using a virtual reality system, we reared mice in conditions of normal or random visuomotor coupling. We recorded the activity of identified excitatory and inhibitory L2/3 neurons in response to transient visuomotor mismatches in both groups of mice. Mismatch responses in excitatory neurons were strongly experience dependent and driven by a transient release from inhibition mediated by somatostatin-positive interneurons. These data are consistent with a model in which L2/3 of V1 computes a difference between an inhibitory visual input and an excitatory locomotion-related input, where the balance between these two inputs is finely tuned by visuomotor experience.
感觉引导行为的出现取决于发育过程中的感觉运动耦合。感觉运动经验如何塑造神经处理尚不清楚。在这里，我们表明，运动输出和视觉反馈之间的耦合对于小鼠初级视觉皮层 (V1) L2/3 层中视觉处理的功能发展是必要的。使用虚拟现实系统，我们在正常或随机视动耦合条件下饲养小鼠。我们记录了两组小鼠在瞬态视动不匹配时鉴定出的兴奋性和抑制性 L2/3 神经元的活性。兴奋性神经元的不匹配反应强烈依赖于经验，并且由 somatostatin 阳性中间神经元介导的抑制的短暂释放驱动。这些数据与一个模型一致，即 V1 的 L2/3 计算抑制性视觉输入和兴奋性运动相关输入之间的差异，其中这两个输入之间的平衡由视动经验精细调节。
