Petersen Christian Lund, Kjærsgaard Jonas Bruun, Kjærgaard Nicolai, Jensen Michael Ulrich, Laursen Mogens Berg
School of Medicine and Health, Aalborg University, Niels Jernes Vej 12 A5, 9220, Aalborg Ø, Denmark.
Department of Orthopaedic Surgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
J Orthop Surg Res. 2017 Jun 12;12(1):89. doi: 10.1186/s13018-017-0592-1.
In a prospective cohort study, we wanted to detect thresholds distinguishing between patients with a satisfactory and an unsatisfactory outcome after total knee replacement (TKR) based on Patient-Reported Outcome Measures (PROMs), namely the Oxford Knee Score (OKS), using patient satisfaction and patient-perceived function as global transition items.
Seventy-three TKR patients completed the OKS questionnaire before surgery and were invited to complete the same questionnaire again 6 (4 to 9) months after surgery. Correlations between outcome measures and anchors were calculated using Pearson's correlation coefficient. Thresholds were established by receiver operating characteristics (ROC) analysis, using multiple anchor-based approaches.
Patients showed a mean increase of 16.5 (SD 9.5) in OKS following TKR. Significant positive correlations were found between outcome measures and anchors. Six different thresholds were determined for outcome measures coupled with satisfaction, patient-perceived function and a combination thereof using a cut-off of 50 and 70.
This study has established a set of clinically meaningful thresholds for Oxford Knee scores that may help to detect TKR patients who might be in need of post-operative evaluation.
在一项前瞻性队列研究中，我们希望基于患者报告结局测量指标（PROMs），即牛津膝关节评分（OKS），以患者满意度和患者感知功能作为整体转变项目，检测全膝关节置换术（TKR）后结局满意和不满意的患者之间的分界点。
73例TKR患者在手术前完成了OKS问卷，并被邀请在术后6（4至9）个月再次完成相同问卷。使用Pearson相关系数计算结局测量指标与锚定指标之间的相关性。采用多种基于锚定的方法，通过受试者工作特征（ROC）分析确定分界点。
TKR后患者的OKS平均增加了16.5（标准差9.5）。在结局测量指标与锚定指标之间发现了显著的正相关。使用截断值50和70，针对与满意度、患者感知功能及其组合相关的结局测量指标确定了六个不同的分界点。
本研究为牛津膝关节评分建立了一组具有临床意义的分界点，这可能有助于检测可能需要术后评估的TKR患者。
