Arbabi-Kalati Fateme, Salimi Saeede, Nabavi Saeede, Rigi Sahebdad, Miri-Moghaddam Masoud
Oral Medicine Department, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran. Email:
Asian Pac J Cancer Prev. 2017 May 1;18(5):1215-1218. doi: 10.22034/APJCP.2017.18.5.1215.
Background: Tobacco use is a harmful habit that causes adverse effects on oral health and plays a most important role in cancer development. Saliva is the first fluid that is exposed to tobacco and its antioxidant system plays an important role in anti-cancer potential; therefore, this study was designed to compare the antioxidant activity and immunologic system of saliva in tobacco users (smokers and smokeless tobacco users) and non-users. Materials and Methods: In this cross-sectional study, unstimulated saliva samples of 75 healthy individuals from three equal groups were investigated. Participants in group A had no periodontal disease and never smoked. Group B had no periodontal disease, never used smokeless tobacco, but had 3 years history of smoking at least 10 cigarettes daily. The twenty-five participants in group C had no periodontal disease and had 1 year history of chewing a 10-g tobacco packet daily. Activity of salivary superoxide dismutase (SOD), salivary glutathione peroxide, and salivary IgA concentration was evaluated. Data were analyzed using SPSS (version 18) and running Kruskal-Wallis test. Statistical significance was set at p<0.05. Results: There were significant differences in the activities of the two enzymes and salivary IgA levels among the three groups. Activity of glutathione peroxide was higher in smokeless tobacco users. (P<0.001) while that of superoxide dismutase was higher in non-tobacco users than users (P<0.001). Salivary IgA levels were higher among smokeless tobacco users (p=0.04). Conclusion: Based on the results of the present study, the use of tobacco products decreases the antioxidative activity of the saliva and increases salivary IgA levels at the same time.
烟草使用是一种有害习惯，会对口腔健康产生不利影响，并且在癌症发展中起着至关重要的作用。唾液是最先接触烟草的体液，其抗氧化系统在抗癌潜力方面发挥着重要作用；因此，本研究旨在比较烟草使用者（吸烟者和无烟烟草使用者）与非使用者唾液的抗氧化活性和免疫系统。材料与方法：在这项横断面研究中，对来自三个相等组的75名健康个体的非刺激性唾液样本进行了调查。A组参与者无牙周疾病且从不吸烟。B组无牙周疾病，从不使用无烟烟草，但有至少3年每天吸至少10支烟的吸烟史。C组的25名参与者无牙周疾病，有1年每天咀嚼10克烟草包的咀嚼史。评估了唾液超氧化物歧化酶（SOD）活性、唾液谷胱甘肽过氧化物酶活性和唾液IgA浓度。使用SPSS（版本18）进行数据分析并进行Kruskal-Wallis检验。设定统计学显著性为p<0.05。结果：三组之间两种酶的活性和唾液IgA水平存在显著差异。无烟烟草使用者的谷胱甘肽过氧化物酶活性较高（P<0.001），而非烟草使用者的超氧化物歧化酶活性高于使用者（P<0.001）。无烟烟草使用者的唾液IgA水平较高（p=0.04）。结论：基于本研究结果，烟草制品的使用会降低唾液的抗氧化活性，同时增加唾液IgA水平。
