韩国老年人群中维生素D状态与不对称二甲基精氨酸（ADMA）浓度之间的关联。

Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population.

作者信息

Choi Hye Rin, Lee Seung Won, Yeom Hyungseon, Jeon Da-Hye, Kim Hyeon Chang, Youm Yoosik

机构信息

Department of Public Health, Yonsei University College of Medicine, Republic of Korea; Cardiovascular and Metabolic Diseases Etiology Research Center, Republic of Korea.

Department of Preventive Medicine, Yonsei University College of Medicine, Republic of Korea.

出版信息

Maturitas. 2017 Aug;102:13-17. doi: 10.1016/j.maturitas.2017.05.002. Epub 2017 May 10.

DOI:10.1016/j.maturitas.2017.05.002

PMID:28610677

Abstract

OBJECTIVES

Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population.

STUDY DESIGN

A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans. We stratified patients by vitamin D status into three groups according to serum 25-hydroxyvitamin D [25(OH)D] level: sufficient (≥30ng/mL, n=25), insufficient (10-<30ng/mL, n=516), and deficient (<10ng/mL, n=110). To measure endothelial dysfunction, ADMA concentration was assayed by high-performance liquid chromatography. The association between 25(OH)D status and ADMA concentration was analyzed by multiple linear regression models.

RESULTS

The mean ADMA concentration was significantly higher in the insufficient 25(OH)D group (0.665μmol/L, p=0.001) and the deficient 25(OH)D group (0.734μmol/L, p<0.001) compared with the sufficient 25(OH)D group (0.589μmol/L). Even after adjusting for sex, age, body mass index, blood pressure, diabetes mellitus, total and HDL cholesterol, estimated glomerular filtration rate (eGFR), smoking status, and drinking status, ADMA concentrations were higher in the insufficient group (β=0.0742μmol/L, p=0.001) and the deficient group (β=0.1417μmol/L, p<0.001) compared than in the sufficient group. In a sex-stratified analysis, 25(OH)D deficiency was associated with higher ADMA levels in both women (p<0.001) and men (p=0.007), while 25(OH)D deficiency was associated with higher ADMA levels in women (p<0.001) but not in men (p=0.631).

CONCLUSION

Our findings suggest that low serum 25(OH)D level may be associated with endothelial dysfunction in elderly Korean people.

摘要

目的

据报道，维生素D缺乏与心血管疾病风险相关。我们在韩国老年人群中研究了维生素D状态与不对称二甲基精氨酸（ADMA）浓度（一种内皮功能障碍标志物）之间的关系。

研究设计

对参与韩国社会生活、健康与老龄化项目（KSHAP）的269名男性和382名女性（平均年龄71.6岁）进行了一项横断面研究，KSHAP是一项基于人群的韩国老年人健康决定因素纵向研究。我们根据血清25-羟基维生素D[25(OH)D]水平将患者按维生素D状态分为三组：充足（≥30ng/mL，n = 25）、不足（10 - <30ng/mL，n = 516）和缺乏（<10ng/mL，n = 110）。为测量内皮功能障碍，采用高效液相色谱法测定ADMA浓度。通过多元线性回归模型分析25(OH)D状态与ADMA浓度之间的关联。

结果

与25(OH)D充足组（0.589μmol/L）相比，25(OH)D不足组（0.665μmol/L，p = 0.001）和25(OH)D缺乏组（0.734μmol/L，p < 0.001）的平均ADMA浓度显著更高。即使在调整了性别、年龄、体重指数、血压、糖尿病、总胆固醇和高密度脂蛋白胆固醇、估计肾小球滤过率（eGFR）、吸烟状况和饮酒状况后，不足组（β = 0.0742μmol/L，p = 0.001）和缺乏组（β = 0.1417μmol/L，p < 0.001）的ADMA浓度仍高于充足组。在按性别分层的分析中，25(OH)D缺乏在女性（p < 0.001）和男性（p = 0.007）中均与较高的ADMA水平相关，而25(OH)D缺乏在女性中与较高的ADMA水平相关（p < 0.001），但在男性中不相关（p = 0.631）。