实验性神经精神疾病模型中的精油：系统评价。
Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.
机构信息
Graduate Program of Animal Science, Federal Rural University of the Semi Arid (UFERSA), Mossoro/RN, Brazil.
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte (UERN), Mossoro/RN, Brazil.
出版信息
Curr Neuropharmacol. 2021;19(10):1738-1759. doi: 10.2174/1570159X19666210421091734.
BACKGROUND
Neural cells undergo functional or sensory loss due to neurological disorders. In addition to environmental or genetic factors, oxidative stress is a major contributor to neurodegeneration. In this context, there has been a growing interest in investigating the effects of EOs (EOs) in recent years, especially in the treatment of neuropathologies. The chemical and biological effects of EOs have led to important treatment tools for the management of various neurological disorders.
OBJECTIVE
In the present study we performed a systematic review that sought to comprehend the neuroprotective effects of different EOs.
METHOD
This work is a systematic review where an electronic search was performed on PubMed, ScienceDirect, Cochrane Library and SciELO (Scientific Electronic Library Online) databases, covering the last 10 years, using "Essential oil" and "Neuroprotective effect" as reference terms.
RESULTS
A total of 9 articles were identified, in which the efficacy of EOs was described in experimental models of anxiety, dementia, oxidative stress, cerebral ischemia, Alzheimer's disease, and oxidative toxicity.
CONCLUSION
EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia, and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.
背景
神经细胞由于神经紊乱而发生功能或感觉丧失。除了环境或遗传因素外，氧化应激是神经退行性变的主要原因。在这种情况下，近年来人们对研究 EO（精油）的影响越来越感兴趣，特别是在治疗神经病理学方面。EO 的化学和生物学作用为管理各种神经紊乱提供了重要的治疗工具。
目的
本研究进行了一项系统评价，旨在了解不同 EO 的神经保护作用。
方法
这是一项系统评价，在 PubMed、ScienceDirect、Cochrane 图书馆和 SciELO（科学电子图书馆在线）数据库中进行了电子检索，涵盖过去 10 年，使用“精油”和“神经保护作用”作为参考术语。
结果
共确定了 9 篇文章，其中描述了 EO 在焦虑、痴呆、氧化应激、脑缺血、阿尔茨海默病和氧化毒性等实验模型中的功效。
结论
来自不同药用植物物种的 EO 在焦虑、痴呆、氧化应激、脑缺血和氧化毒性等神经紊乱方面表现出积极反应。因此，EO 有可能作为治疗神经紊乱的替代药物。
Zotero 插件