• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

实验性神经精神疾病模型中的精油：系统评价。

Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.

机构信息

Graduate Program of Animal Science, Federal Rural University of the Semi Arid (UFERSA), Mossoro/RN, Brazil.

Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte (UERN), Mossoro/RN, Brazil.

出版信息

Curr Neuropharmacol. 2021;19(10):1738-1759. doi: 10.2174/1570159X19666210421091734.

DOI:10.2174/1570159X19666210421091734
PMID:33882807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8977636/
Abstract

BACKGROUND

Neural cells undergo functional or sensory loss due to neurological disorders. In addition to environmental or genetic factors, oxidative stress is a major contributor to neurodegeneration. In this context, there has been a growing interest in investigating the effects of EOs (EOs) in recent years, especially in the treatment of neuropathologies. The chemical and biological effects of EOs have led to important treatment tools for the management of various neurological disorders.

OBJECTIVE

In the present study we performed a systematic review that sought to comprehend the neuroprotective effects of different EOs.

METHOD

This work is a systematic review where an electronic search was performed on PubMed, ScienceDirect, Cochrane Library and SciELO (Scientific Electronic Library Online) databases, covering the last 10 years, using "Essential oil" and "Neuroprotective effect" as reference terms.

RESULTS

A total of 9 articles were identified, in which the efficacy of EOs was described in experimental models of anxiety, dementia, oxidative stress, cerebral ischemia, Alzheimer's disease, and oxidative toxicity.

CONCLUSION

EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia, and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.

摘要

背景

神经细胞由于神经紊乱而发生功能或感觉丧失。除了环境或遗传因素外，氧化应激是神经退行性变的主要原因。在这种情况下，近年来人们对研究 EO（精油）的影响越来越感兴趣，特别是在治疗神经病理学方面。EO 的化学和生物学作用为管理各种神经紊乱提供了重要的治疗工具。

目的

本研究进行了一项系统评价，旨在了解不同 EO 的神经保护作用。

方法

这是一项系统评价，在 PubMed、ScienceDirect、Cochrane 图书馆和 SciELO（科学电子图书馆在线）数据库中进行了电子检索，涵盖过去 10 年，使用“精油”和“神经保护作用”作为参考术语。

结果

共确定了 9 篇文章，其中描述了 EO 在焦虑、痴呆、氧化应激、脑缺血、阿尔茨海默病和氧化毒性等实验模型中的功效。

结论

来自不同药用植物物种的 EO 在焦虑、痴呆、氧化应激、脑缺血和氧化毒性等神经紊乱方面表现出积极反应。因此，EO 有可能作为治疗神经紊乱的替代药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/963c2e761eba/CN-19-1738_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/e15c22129205/CN-19-1738_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/9601c7e1cdeb/CN-19-1738_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/5cae4bf3040f/CN-19-1738_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/fd10fa50af53/CN-19-1738_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/963c2e761eba/CN-19-1738_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/e15c22129205/CN-19-1738_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/9601c7e1cdeb/CN-19-1738_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/5cae4bf3040f/CN-19-1738_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/fd10fa50af53/CN-19-1738_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f5/8977636/963c2e761eba/CN-19-1738_F5.jpg

相似文献

1
Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.实验性神经精神疾病模型中的精油：系统评价。
Curr Neuropharmacol. 2021;19(10):1738-1759. doi: 10.2174/1570159X19666210421091734.
2
Astragaloside IV Supplementation Promotes A Neuroprotective Effect in Experimental Models of Neurological Disorders: A Systematic Review.黄芪甲苷补充剂在神经疾病实验模型中具有神经保护作用：系统评价。
Curr Neuropharmacol. 2019;17(7):648-665. doi: 10.2174/1570159X16666180911123341.
3
Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants.芳香药用植物精油的神经保护和抗衰老潜力
Front Aging Neurosci. 2017 May 30;9:168. doi: 10.3389/fnagi.2017.00168. eCollection 2017.
4
Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity.薰衣草和芫荽精油及其主要成分芳樟醇对淀粉样β神经毒性有保护作用。
Phytother Res. 2021 Jan;35(1):486-493. doi: 10.1002/ptr.6827. Epub 2020 Aug 12.
5
Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article.香芹酚作为神经疾病潜在神经保护剂的系统评价文章。
CNS Neurol Disord Drug Targets. 2021;20(10):942-953. doi: 10.2174/1871527320666210506185042.
6
Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review.精油作为一种潜在的神经保护疗法，用于治疗与年龄相关的神经退行性疾病：综述。
Molecules. 2021 Feb 19;26(4):1107. doi: 10.3390/molecules26041107.
7
Pinus halepensis essential oil attenuates the toxic Alzheimer's amyloid beta (1-42)-induced memory impairment and oxidative stress in the rat hippocampus.油松精油可减轻阿尔茨海默病淀粉样β（1-42）诱导的大鼠海马记忆损伤和氧化应激。
Biomed Pharmacother. 2019 Apr;112:108673. doi: 10.1016/j.biopha.2019.108673. Epub 2019 Feb 20.
8
Citrus spp. essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly (Drosophila melanogaster) model of Alzheimer's Disease.柑橘属植物精油改善行为模式，抑制胆碱酯酶和单胺氧化酶活性，并在阿尔茨海默病果蝇（Drosophila melanogaster）模型中产生活性物质。
J Food Biochem. 2021 Mar;45(3):e13558. doi: 10.1111/jfbc.13558. Epub 2020 Nov 11.
9
Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus.松柏类精油通过调节大鼠海马 BDNF 和 ARC 表达逆转淀粉样β1-42 作用。
CNS Neurol Disord Drug Targets. 2022;21(1):85-94. doi: 10.2174/1871527320666210303111537.
10
Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer's disease amyloidosis model.四纹麻精油可减轻阿尔茨海默病淀粉样变性模型的认知缺陷和大脑氧化应激。
Phytomedicine. 2019 Mar 15;56:57-63. doi: 10.1016/j.phymed.2018.10.032. Epub 2018 Oct 31.

引用本文的文献

1
Neuroprotective effects of essential oils in animal models of Alzheimer's and Parkinson's disease: a systematic review.精油在阿尔茨海默病和帕金森病动物模型中的神经保护作用：一项系统综述。
PeerJ. 2025 Jul 10;13:e19643. doi: 10.7717/peerj.19643. eCollection 2025.
2
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease.挥发油的神经保护作用：对阿尔茨海默病化学特征、特性、神经化学机制及临床前研究的见解。
Inflammopharmacology. 2025 Feb;33(2):627-667. doi: 10.1007/s10787-024-01626-5. Epub 2025 Jan 22.
3
Carvacrol Essential Oil as a Neuroprotective Agent: A Review of the Study Designs and Recent Advances.

本文引用的文献

1
Effect of Cocoa and Cocoa Products on Cognitive Performance in Young Adults.可可及可可制品对青年成年人认知表现的影响。
Nutrients. 2020 Nov 30;12(12):3691. doi: 10.3390/nu12123691.
2
Resveratrol Mitigates Cerebral Ischemic Injury by Altering Levels of Trace Elements, Toxic Metal, Lipid Peroxidation, and Antioxidant Activity.白藜芦醇通过改变微量元素、有毒金属、脂质过氧化和抗氧化活性水平来减轻脑缺血损伤。
Biol Trace Elem Res. 2021 Oct;199(10):3718-3727. doi: 10.1007/s12011-020-02497-x. Epub 2020 Nov 23.
3
Green Route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil.
香芹酚精油作为一种神经保护剂：研究设计与最新进展综述
Molecules. 2024 Dec 30;30(1):104. doi: 10.3390/molecules30010104.
4
Aromatic Plant-Based Functional Foods: A Natural Approach to Manage Cardiovascular Diseases.芳香植物功能性食品：管理心血管疾病的自然方法。
Molecules. 2023 Jun 30;28(13):5130. doi: 10.3390/molecules28135130.
5
Inhalation Aromatherapy Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders.吸入式芳香疗法 脑靶向鼻腔给药：天然挥发物或精油对情绪障碍的影响
Front Pharmacol. 2022 Apr 12;13:860043. doi: 10.3389/fphar.2022.860043. eCollection 2022.
从特级初榨橄榄油中分离和纯化羟基酪醇、酪醇、橄榄苦苷和油橄榄苦苷的绿色路线。
Molecules. 2020 Aug 11;25(16):3654. doi: 10.3390/molecules25163654.
4
Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity.薰衣草和芫荽精油及其主要成分芳樟醇对淀粉样β神经毒性有保护作用。
Phytother Res. 2021 Jan;35(1):486-493. doi: 10.1002/ptr.6827. Epub 2020 Aug 12.
5
Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.茶多酚通过调节海马神经元中的BDNF-TrkB/Akt和Erk1/2信号轴减轻星形孢菌素诱导的细胞毒性和凋亡。
IBRO Rep. 2020 Apr 19;8:115-121. doi: 10.1016/j.ibror.2020.04.002. eCollection 2020 Jun.
6
A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2-73) Phase 2a clinical study.一种利用人工智能的精准医学框架，用于识别和确认阿尔茨海默病治疗反应的基因组生物标志物：对布拉克美辛（ANAVEX2-73）2a期临床研究的分析。
Alzheimers Dement (N Y). 2020 Apr 19;6(1):e12013. doi: 10.1002/trc2.12013. eCollection 2020.
7
Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel.白藜芦醇通过调节 TRPM2 通道减轻缺氧诱导的神经元细胞死亡、炎症和线粒体氧化应激。
Sci Rep. 2020 Apr 15;10(1):6449. doi: 10.1038/s41598-020-63577-5.
8
In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders.体内、体外和体内研究表明白藜芦醇类似物是神经炎症性疾病的一种有潜力的替代药物。
Life Sci. 2020 May 15;249:117538. doi: 10.1016/j.lfs.2020.117538. Epub 2020 Mar 10.
9
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.白藜芦醇通过 SIRT1 依赖调控 BDNF 表达减轻七氟醚诱导的发育期小鼠神经毒性。
Oxid Med Cell Longev. 2020 Feb 18;2020:9018624. doi: 10.1155/2020/9018624. eCollection 2020.
10
Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology.姜黄素作为急性和慢性脑病理形式的潜在神经保护剂。
Biochemistry (Mosc). 2020 Feb;85(2):167-176. doi: 10.1134/S0006297920020042.