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持续性剖宫产瘢痕妊娠的临床特征及挽救性处理

Clinical characteristics and salvage management of persistent cesarean scar pregnancy.

作者信息

Ying Xue, Zheng Wei, Zhao Li, Zhou Mi, Chen Zhengyun

机构信息

Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Hainan Province, Haikou, China.

出版信息

J Obstet Gynaecol Res. 2017 Aug;43(8):1293-1298. doi: 10.1111/jog.13367. Epub 2017 Jun 14.

Abstract

AIM

The study was conducted to illustrate the clinical characteristics and treatment outcomes of patients with persistent cesarean scar pregnancy (PCSP).

METHODS

During a six-year period, 38 cases of PCSP were diagnosed and treated conservatively to preserve fertility. The clinical presentations, imaging findings and treatment outcomes of these patients were reviewed.

RESULTS

Fourteen out of 38 women (37%) presenting with PCSP suffered heavy vaginal bleeding. Gestational age at diagnosis was 73.1 ± 21.7 days. The maximum diameter of the PCSP mass was 3.6 ± 1.6 cm. The presence of a rich vascular pattern in the area of the PCSP mass was detected by ultrasound in 33/38 (87%) patients. Six patients with a PCSP gestational age of 64.2 ± 6.2 days and a mass diameter of 2.5 ± 0.6 cm were successfully treated with medical treatment alone and 32 patients with a gestational age of 74.8 ± 23.1 days and a mass diameter of 3.8 ± 1.6 cm were successfully treated with surgical or combined treatment.

CONCLUSIONS

Patients with PCSP are diagnosed at advanced gestational age and are more prone to heavy bleeding. Surgery is the main treatment for PCSP. Medical treatment of PCSP has become an attractive alternative, especially for hemodynamically stable patients with a PCSP mass with a maximum diameter of < 3.5 cm.

摘要

目的

本研究旨在阐述持续性剖宫产瘢痕妊娠(PCSP)患者的临床特征及治疗效果。

方法

在六年期间,共诊断出38例PCSP患者,并对其进行了保留生育功能的保守治疗。回顾了这些患者的临床表现、影像学检查结果及治疗效果。

结果

38例PCSP患者中,14例(37%)出现严重阴道出血。诊断时的孕周为73.1±21.7天。PCSP包块的最大直径为3.6±1.6厘米。38例患者中有33例(87%)经超声检查发现PCSP包块区域存在丰富的血管形态。6例PCSP孕周为64.2±6.2天、包块直径为2.5±0.6厘米的患者仅通过药物治疗成功治愈,32例孕周为74.8±23.1天、包块直径为3.8±1.6厘米的患者通过手术或联合治疗成功治愈。

结论

PCSP患者多在孕晚期被诊断出来,且更容易发生大出血。手术是PCSP的主要治疗方法。PCSP的药物治疗已成为一种有吸引力的替代方案,特别是对于血流动力学稳定、PCSP包块最大直径<3.5厘米的患者。

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本文引用的文献

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Cesarean scar pregnancy: a systematic review of treatment studies.剖宫产瘢痕妊娠:治疗研究的系统评价
Fertil Steril. 2016 Apr;105(4):958-67. doi: 10.1016/j.fertnstert.2015.12.130. Epub 2016 Jan 18.

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