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2
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人类免疫缺陷病毒感染者自发干扰素-γ分泌升高

Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons.

作者信息

Sparks Rachel, Koelle David M, Stern Joshua E, Dhanireddy Shireesha

机构信息

Departments ofMedicine.

Global Health.

出版信息

Open Forum Infect Dis. 2017 Jun 7;4(2):ofx055. doi: 10.1093/ofid/ofx055. eCollection 2017 Spring.

DOI:10.1093/ofid/ofx055
PMID:28616443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5461986/
Abstract

Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the "nil" value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.

摘要

人类免疫缺陷病毒（HIV）感染中的免疫激活是一种已被充分描述的现象。我们发现，通过结核感染T细胞检测（QuantiFERON-TB Gold test）中的“零”值来衡量，即使病毒载量较低，HIV患者相较于非HIV受试者也有更高水平的干扰素（IFN）-γ分泌。这可能反映出即便HIV得到了最佳管理，免疫激活仍在持续。