de Lima Filipe Dinato, Bottaro Martim, de Oliveira Valeriano Ritielli, Cruz Lorena, Battaglini Claudio L, Vieira Carlos Alexandre, de Oliveira Ricardo Jacó
1 University of Brasília, Brasília, Brazil.
2 University of North Carolina at Chapel Hill, NC, USA.
Integr Cancer Ther. 2018 Jun;17(2):299-305. doi: 10.1177/1534735417712009. Epub 2017 Jun 15.
The purpose of this study was to compare fatigue, strength, body composition, muscle thickness, and muscle quality between Hodgkin's lymphoma survivors (HLS) and apparently healthy subjects matched by age, gender, and physical activity levels (CON). Twelve HLS (32.16 ± 8.06) and 36 CON (32.42 ± 7.64) were enrolled in the study. Fatigue was assessed using the 20-item Multidimensional Fatigue Inventory, muscle strength using an isokinetic dynamometer, body composition using dual-energy X-ray absorptiometry, and thickness and muscle quality using B-mode ultrasound. Differences between HLS and CON were analyzed using independent samples t tests. No significant differences were observed between groups for any demographic characteristics: age ( P = .922), weight ( P = .943), height ( P = .511), body mass index ( P = .796), fat mass ( P = .688), fat-free mass ( P = .520), and percent body fat ( P = .446). No significant differences were observed for strength (peak torque; P = .552), relative peak torque ( P = .200), muscle thickness ( P > .05) and muscle quality ( P > .05). However, self-perceived fatigue was significantly higher in HLS than in CON ( P = .009). It appears that when HLS are matched by age and physical activity levels to CON, no significant difference in body composition, muscle thickness, muscle quality, or strength is observed. Self-perceived fatigue, as predicted, is higher in HLS, which may have implications and should be considered when prescribing exercise training to this cancer population.
本研究的目的是比较霍奇金淋巴瘤幸存者（HLS）与年龄、性别和身体活动水平相匹配的明显健康受试者（CON）之间的疲劳、力量、身体成分、肌肉厚度和肌肉质量。12名HLS（32.16±8.06）和36名CON（32.42±7.64）参与了本研究。使用20项多维疲劳量表评估疲劳，使用等速测力计评估肌肉力量，使用双能X线吸收法评估身体成分，使用B型超声评估厚度和肌肉质量。使用独立样本t检验分析HLS和CON之间的差异。两组在任何人口统计学特征上均未观察到显著差异：年龄（P = 0.922）、体重（P = 0.943）、身高（P = 0.511）、体重指数（P = 0.796）、脂肪量（P = 0.688）、去脂体重（P = 0.520）和体脂百分比（P = 0.446）。在力量（峰值扭矩；P = 0.552）、相对峰值扭矩（P = 0.200）、肌肉厚度（P>0.05）和肌肉质量（P>0.05）方面未观察到显著差异。然而，HLS的自我感知疲劳明显高于CON（P = 0.009）。当HLS在年龄和身体活动水平上与CON相匹配时，在身体成分、肌肉厚度、肌肉质量或力量方面未观察到显著差异。正如所预测的，HLS的自我感知疲劳更高，这可能具有重要意义，在为该癌症人群制定运动训练时应予以考虑。
