Zhang Peng, Shen Zhangqi, Zhang Chunping, Song Li, Wang Bing, Shang Jun, Yue Xiuying, Qu Zhina, Li Xinnan, Wu Liqin, Zheng Yongjun, Aditya Anand, Wang Yang, Xu Shixin, Wu Congming
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
China Institute of Veterinary Drug Control, Beijing 100081, China.
Vet Microbiol. 2017 May;203:49-55. doi: 10.1016/j.vetmic.2017.02.008. Epub 2017 Feb 20.
The objective of this study was to investigate the antimicrobial resistance trend in Escherichia coli from food animals in China. During 2008-2015, a total of 15,130 E. coli were isolated from chicken and swine from seven provinces. The susceptibilities of these isolates to nine classes of antimicrobial agents were determined using broth microdilution susceptibility method. The findings of this study include: (1) multi-drug resistance was highly prevalent in E. coli; (2) these E. coli isolates showed high resistant rate (>80%) to several old drugs, including ampicillin, tetracycline and sulfisoxazole; (3) increasing resistance to colistin, florfenicol and ceftiofur was observed; (4) the E. coli isolates from different provinces had different resistance patterns. All these data highlight the rising problem of antimicrobial resistance. It is urgent to improve the management of animal production and enhance the proper use of antimicrobials in China as well as the other countries.
本研究的目的是调查中国食用动物源大肠杆菌的耐药性趋势。2008年至2015年期间，从七个省份的鸡和猪中总共分离出15130株大肠杆菌。使用肉汤微量稀释药敏试验方法测定了这些分离株对九类抗菌药物的敏感性。本研究的结果包括：（1）多重耐药性在大肠杆菌中非常普遍；（2）这些大肠杆菌分离株对几种老药，包括氨苄西林、四环素和磺胺异恶唑，显示出高耐药率（>80%）；（3）观察到对黏菌素、氟苯尼考和头孢噻呋的耐药性增加；（4）来自不同省份的大肠杆菌分离株具有不同的耐药模式。所有这些数据都凸显了抗菌药物耐药性问题的日益严重。在中国以及其他国家，迫切需要改善动物生产管理并加强抗菌药物的合理使用。
