Kwok Zhi Hao, Tay Yvonne
Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, Singapore 117599.
Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, Singapore 117599
Biochem Soc Trans. 2017 Jun 15;45(3):805-812. doi: 10.1042/BST20160376.
Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are highly diverse in terms of characteristics and functions. Advances in high-throughput sequencing platforms have enabled the rapid discovery and identification of lncRNAs as key regulatory molecules involved in various cellular processes and their dysregulation in various human diseases. Here, we summarize the current knowledge of the functions and underlying mechanisms of lncRNA activity with a particular focus on cancer biology. We also discuss the potential of lncRNAs as diagnostic and therapeutic targets for clinical applications.
长链非编码RNA（lncRNAs）是最大的转录本类别之一，在特征和功能方面高度多样。高通量测序平台的进展使得能够快速发现和鉴定lncRNAs，它们是参与各种细胞过程的关键调节分子，并且在各种人类疾病中存在失调。在此，我们总结了lncRNA活性的功能和潜在机制的当前知识，特别关注癌症生物学。我们还讨论了lncRNAs作为临床应用中诊断和治疗靶点的潜力。
