State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, Jiangsu 211800, China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, Jiangsu 211800, China.
Bioresour Technol. 2017 Dec;245(Pt B):1710-1717. doi: 10.1016/j.biortech.2017.05.209. Epub 2017 Jun 3.
Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches.
琥珀酸是一种四碳二羧酸，由于其作为食品、化工和制药行业许多工业重要化学品的前体的广泛用途，引起了广泛关注。面对原油供需短缺和可持续发展的需求，利用可再生资源生物生产琥珀酸成为了全球关注的话题。近几十年来，人们已经开发出了强大的生产菌株选择、模型菌株的代谢工程以及琥珀酸生产的工艺优化。本文综述了琥珀酸的生产菌和培养技术，重点介绍了一些成功的代谢工程方法。
