Cui Lu-Ying, Guo Ni-Ni, Li Yu-Lin, Li Meng, Ding Ming-Xing
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, P.R. China.
Livestock and Poultry Breeding Center of Hubei Province, Wuhan, Hubei, P.R. China.
Vet Anaesth Analg. 2017 Jul;44(4):959-967. doi: 10.1016/j.vaa.2016.10.003. Epub 2017 Jan 12.
To investigate physiological and antinociceptive effects of electroacupuncture (EA) with lidocaine epidural nerve block in goats.
Prospective experimental trial.
Forty-eight hybrid male goats weighing 27 ± 2 kg.
The goats were randomly assigned to six groups: L2.2, epidural lidocaine (2.2 mg kg); L4.4, epidural lidocaine (4.4 mg kg); EA; EA-L1.1, EA with epidural lidocaine (1.1 mg kg); EA-L2.2, EA with epidural lidocaine (2.2 mg kg); and EA-L4.4, EA with epidural lidocaine (4.4 mg kg). EA was administered for 120 minutes. Epidural lidocaine was administered 25 minutes after EA started. Nociceptive thresholds of flank and thigh regions, abdominal muscle tone, mean arterial pressure (MAP), heart rate (HR), respiratory frequency (f) and rectal temperature were recorded at 30, 60, 90, 120, 150 and 180 minutes.
Lidocaine dose-dependently increased nociceptive thresholds. There were no differences in nociceptive thresholds between L4.4 and EA from 30 to 120 minutes. The threshold in EA-L2.2 was lower than in EA-L4.4 from 30 to 120 minutes, but higher than in EA-L1.1 from 30 to 150 minutes or in L4.4 from 30 to 180 minutes. The abdominal muscle tone in EA-L2.2 was higher at 30 minutes, but lower at 90 and 120 minutes than at 0 minutes. There were no differences in muscle tone between L4.4 and L2.2 or EA-L4.4, and between any two of the three EA-lidocaine groups from 0 to 180 minutes. The f and HR decreased in L4.4 at 60 and 90 minutes compared with 0 minutes. No differences in f, HR, MAP and temperature among the groups occurred from 30 to 180 minutes.
EA combined with 2.2 mg kg epidural lidocaine provides better antinociceptive effect than 4.4 mg kg epidural lidocaine alone in goats. EA provided antinociception and allowed a decrease in epidural lidocaine dose.
探讨电针（EA）联合利多卡因硬膜外神经阻滞对山羊的生理和镇痛作用。
前瞻性实验性试验。
48只体重27±2 kg的杂种雄性山羊。
将山羊随机分为6组：L2.2组，硬膜外注射利多卡因（2.2 mg/kg）；L4.4组，硬膜外注射利多卡因（4.4 mg/kg）；EA组；EA-L1.1组，电针联合硬膜外注射利多卡因（1.1 mg/kg）；EA-L2.2组，电针联合硬膜外注射利多卡因（2.2 mg/kg）；EA-L4.4组，电针联合硬膜外注射利多卡因（4.4 mg/kg）。电针治疗120分钟。在电针开始25分钟后给予硬膜外利多卡因。分别于30、60、90、120、150和180分钟记录胁腹和大腿区域的痛觉阈值、腹肌张力、平均动脉压（MAP）、心率（HR）、呼吸频率（f）和直肠温度。
利多卡因剂量依赖性地提高痛觉阈值。在30至120分钟内，L4.4组和EA组的痛觉阈值无差异。在30至120分钟内，EA-L2.2组的阈值低于EA-L4.4组，但在30至150分钟内高于EA-L1.1组，在30至180分钟内高于L4.4组。EA-L2.2组在30分钟时腹肌张力较高，但在90和120分钟时低于0分钟时。在0至180分钟内，L4.4组和L2.2组或EA-L4.4组之间以及三个电针-利多卡因组中的任意两组之间的肌张力无差异。与0分钟相比，L4.4组在60和90分钟时f和HR降低。在30至180分钟内，各组之间的f、HR、MAP和体温无差异。
在山羊中，电针联合2.2 mg/kg硬膜外利多卡因比单独使用4.4 mg/kg硬膜外利多卡因具有更好的镇痛效果。电针具有镇痛作用，并可降低硬膜外利多卡因的剂量。
