Thyagarajan Anita, Sahu Ravi P
1 Wright State University, Dayton, OH, USA.
Integr Cancer Ther. 2018 Jun;17(2):210-216. doi: 10.1177/1534735416681639. Epub 2017 Mar 20.
Antioxidants play important roles in the maintenance of cellular integrity and thus are critical in maintaining the homeostasis of the host immune system. A balance between the levels of pro-oxidants and antioxidants defines the cellular fate of genomic integrity via maintaining the redox status of the cells. An aberration in this balance modulates host immunity that affects normal cellular signaling pathways resulting in uncontrolled proliferation of cells leading to neocarcinogenesis. For decades, there have been scientific debates on the use of antioxidants for the treatment of human cancers. This review is focused on current updates on the implications of antioxidant use as adjuncts in cancer therapy with an emphasis on immunomodulation and radiosensitization.
抗氧化剂在维持细胞完整性方面发挥着重要作用，因此对于维持宿主免疫系统的稳态至关重要。促氧化剂和抗氧化剂水平之间的平衡通过维持细胞的氧化还原状态来决定基因组完整性的细胞命运。这种平衡的失调会调节宿主免疫，影响正常的细胞信号通路，导致细胞不受控制地增殖，进而引发肿瘤发生。几十年来，关于使用抗氧化剂治疗人类癌症一直存在科学争论。本综述聚焦于抗氧化剂作为癌症治疗辅助手段的应用的最新进展，重点在于免疫调节和放射增敏作用。
