Greupner Theresa, Schneider Inga, Hahn Andreas
a Institute of Food Science and Human Nutrition, Leibniz University Hannover , Hannover , Germany.
J Am Coll Nutr. 2017 Jul;36(5):386-390. doi: 10.1080/07315724.2017.1299651. Epub 2017 Jun 19.
The aim of the present study was to compare the bioavailability of calcium from 3 mineral waters with different concentrations of minerals with that of milk and a calcium supplement.
A single-center, randomized controlled trial with a crossover design with 21 healthy men and women was conducted at the Institute of Food Science and Human Nutrition, Leibniz University Hannover. The participants consumed the 5 test products providing 300 mg of calcium each on 5 examination days with 1-week wash-out phases in between. Primary outcome variables were the area under the curve of serum calcium levels for 10-hour (AUC) and 24-hour urinary calcium excretion.
In all groups, no significant differences in the AUC of serum calcium levels as well as in the 24-hour urinary calcium excretion were observed. Likewise, mean changes in serum phosphate and urinary phosphate, as well as serum parathormone, showed no differences between the groups.
Given an equivalent bioavailability of calcium in all test products, neither a high concentration of SO or of HCO influenced the bioavailability of calcium. Accordingly, the use of mineral water with high concentrations of calcium constitutes a calorie-free calcium source that can improve calcium supply.
本研究旨在比较3种矿物质浓度不同的矿泉水与牛奶及一种钙补充剂中钙的生物利用度。
在汉诺威莱布尼茨大学食品科学与人类营养研究所开展了一项单中心、随机对照的交叉试验，共有21名健康男性和女性参与。参与者在5个检查日服用5种均提供300毫克钙的测试产品，中间间隔1周的洗脱期。主要结局变量为血清钙水平10小时曲线下面积（AUC）和24小时尿钙排泄量。
在所有组中，未观察到血清钙水平AUC以及24小时尿钙排泄量存在显著差异。同样，血清磷酸盐和尿磷酸盐以及血清甲状旁腺激素的平均变化在各组之间也无差异。
鉴于所有测试产品中钙的生物利用度相当，高浓度的硫酸根或碳酸氢根均未影响钙的生物利用度。因此，使用高钙矿泉水可构成一种无热量的钙源，有助于改善钙供应。
