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对BST-2限制的敏感性与正布尼亚病毒宿主范围相关。

Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range.

作者信息

Varela Mariana, Piras Ilaria M, Mullan Catrina, Shi Xiaohong, Tilston-Lunel Natasha L, Pinto Rute Maria, Taggart Aislynn, Welch Stephen R, Neil Stuart J D, Kreher Felix, Elliott Richard M, Palmarini Massimo

机构信息

MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom.

MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom.

出版信息

Virology. 2017 Sep;509:121-130. doi: 10.1016/j.virol.2017.06.017. Epub 2017 Jun 17.

DOI:10.1016/j.virol.2017.06.017
PMID:28628828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5526858/
Abstract

Orthobunyaviruses include several recently emerging viruses of significant medical and veterinary importance. There is currently very limited understanding on what determines the host species range of these pathogens. In this study we discovered that BST-2/tetherin restricts orthobunyavirus replication in a host-specific manner. We show that viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (Schmallenberg virus and others) are restricted by human BST-2 but not by the sheep orthologue. We also show that BST-2 blocks orthobunyaviruses replication by reducing the amount of envelope glycoprotein into viral particles egressing from infected cells. This is the first study identifying a restriction factor that correlates with species susceptibility to orthobunyavirus infection. This work provides insight to help us dissect the adaptive changes that bunyaviruses require to cross the species barrier and emerge into new species.

摘要

正布尼亚病毒包括几种最近出现的、具有重大医学和兽医学意义的病毒。目前对于决定这些病原体宿主物种范围的因素了解非常有限。在本研究中，我们发现BST-2/拴系蛋白以宿主特异性方式限制正布尼亚病毒的复制。我们表明，具有人嗜性的病毒（奥罗普切病毒和拉克罗斯病毒）受到绵羊BST-2的限制，但不受人同源物的限制，而具有反刍动物嗜性的病毒（施马伦贝格病毒等）受到人BST-2的限制，但不受绵羊同源物的限制。我们还表明，BST-2通过减少从感染细胞中释放出的病毒颗粒中包膜糖蛋白的量来阻断正布尼亚病毒的复制。这是第一项鉴定出与正布尼亚病毒感染物种易感性相关的限制因子的研究。这项工作为帮助我们剖析布尼亚病毒跨越物种屏障并出现新物种所需的适应性变化提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/420ac4591204/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/48f83c872d0c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/41a77ab6d974/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/37974c46816a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/8209f0dd1fe5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/420ac4591204/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/48f83c872d0c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/41a77ab6d974/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/37974c46816a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/8209f0dd1fe5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75d/5526858/420ac4591204/gr5.jpg

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