Paganelli R, Pallone F, Montano S, Le Moli S, Matricardi P M, Fais S, Paoluzi P, D'Amelio R, Aiuti F
Int Arch Allergy Appl Immunol. 1985;78(1):81-5. doi: 10.1159/000233867.
We studied the class-specific antibody response to the cow's milk antigen beta-lactoglobulin (beta-LG) in sera from patients with ulcerative colitis and Crohn's disease. IgG and IgM to beta-LG were significantly higher in patients when compared to healthy non-atopic controls, whereas IgA values were similar, and specific IgE absent in all groups. No correlation between IgG- or IgM-containing immune complexes was found with the corresponding isotype of antibody to beta-LG; however, IgM complexes correlated with serum total IgM in ulcerative colitis. In these patients, IgG antibodies were higher in active cases, whereas IgM increased in patients without signs of disease activity. Antibody titers did not correlate with disease duration or administration of antiinflammatory drugs. This pattern of anti-beta-LG reactivity suggests that the presence of intestinal lesions may be revealed by the selective increase of some antibody isotypes to orally administered antigens. Enhanced mucosal permeability may be studied by this type of serological analysis.
我们研究了溃疡性结肠炎和克罗恩病患者血清中针对牛奶抗原β-乳球蛋白（β-LG）的类特异性抗体反应。与健康的非特应性对照相比，患者体内针对β-LG的IgG和IgM显著更高，而IgA值相似，且所有组中均未检测到特异性IgE。未发现含IgG或IgM的免疫复合物与针对β-LG的相应抗体同种型之间存在相关性；然而，在溃疡性结肠炎中，IgM复合物与血清总IgM相关。在这些患者中，活动期病例的IgG抗体更高，而无疾病活动迹象的患者IgM升高。抗体滴度与疾病持续时间或抗炎药物的使用无关。这种抗β-LG反应模式表明，肠道病变的存在可能通过对口服抗原的某些抗体同种型的选择性增加而显现。这种血清学分析类型可用于研究黏膜通透性增强的情况。
