Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Department of Pediatric Dentistry, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Sci Rep. 2017 Jun 20;7(1):3906. doi: 10.1038/s41598-017-04422-0.
As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.
随着老年正畸患者数量的增加，绝经后骨质疏松症对正畸牙齿移动（OTM）的影响引起了广泛关注，因为 OTM 依赖于牙槽骨重塑。OTM 是否会在骨质疏松症情况下导致随后的牙槽骨丢失，以及对牙槽骨健康是否有害，这一问题仍有待解答。本研究旨在阐明 OTM 对骨质疏松症大鼠牙槽骨的影响。由于压力区骨吸收增加，OVX 大鼠中的 OTM 加速。同时，在 OVX 大鼠的 OTM 期间，张力区促进了合成代谢的骨形成。牙槽骨的 micro-CT 分析显示，在 OTM 后的第 21 天，与非 OTM 大鼠相比，OTM 组的 BMD、BV/TV 和 Tb.Th. 降低，这表明 OTM 在 OVX 大鼠的 OTM 期间导致了牙槽骨丢失。然而，在 OTM 后 3 个月，OVX 大鼠的 OTM 诱导的骨丢失可以恢复。因此，我们的研究结果表明，增加的成骨作用可能会补偿 OTM 期间和之后的骨吸收增加，并使 OVX 大鼠能够有效地加速 OTM。
