Jenssen T G, Burhol P G, Jorde R
Scand J Gastroenterol. 1985 Aug;20(6):762-6. doi: 10.3109/00365528509089210.
A 1-l soap enema given to nine healthy volunteers elicited significantly elevated plasma levels of vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK), together with a transient somatostatin peak. These rises coincided with significant rises both in systolic and diastolic blood pressure, whereas plasma levels of motilin and pancreatic polypeptide remained unchanged. It is suggested that the peptide releases are of colonic origin and that VIP and CCK may play mediatory roles in the enema-induced defecation.
给9名健康志愿者使用1升肥皂水灌肠后，血管活性肠肽（VIP）和胆囊收缩素（CCK）的血浆水平显著升高，同时伴有生长抑素的短暂峰值。这些升高与收缩压和舒张压的显著升高同时出现，而胃动素和胰多肽的血浆水平保持不变。提示这些肽的释放源自结肠，且VIP和CCK可能在灌肠诱导的排便中起介导作用。
