Zhang J-X, Zhu G-P, Zhang B-L, Cheng Y-Y
Department of Endocrinology, Wuhan General Hospital of the Chinese People's Liberation Army, Wuhan, China.
J Hum Hypertens. 2017 Oct;31(10):611-615. doi: 10.1038/jhh.2017.44. Epub 2017 Jun 22.
Retinol-binding protein 4 (RBP4) has been reported involving in the occurrence and development of hypertension. However, to date, few data are available on the correlation between serum RBP4 level and blood pressure (BP) in prehypertension. Therefore, this association was investigated in prehypertensive Chinese. Overall, 160 subjects with prehypertension (Pre-HT group) and 160 subjects with normal BP (NBP group) were recruited in this study. The subjects were divided into the following four subgroups according to body mass index (BMI): obese Pre-HT subgroup; non-obese Pre-HT subgroup; obese NBP subgroup; and non-obese NBP subgroup (n=80 in each). Anthropometric parameters, systolic BP (SBP), diastolic BP (DBP) and several biochemical parameters were measured. Fasting insulin was evaluated by radioimmunoassay. Serum RBP4 level was measured by enzyme-linked immunosorbent assay. The Pre-HT group had higher levels of serum RBP4 level than did the NBP group (P<0.001). Moreover, higher RBP4 levels were identified in the obese Pre-HT subgroup relative to the non-obese Pre-HT subgroup (P=0.005). However, no difference in RBP4 level was identified between the obese and the non-obese NBP subgroups (P=0.317). RBP4 level was positively correlated with BMI (r=0.226, P=0.001), SBP (r=0.468, P<0.001) and DBP (r=0.358, P<0.001) after adjustment for age, sex, smoking status and alcohol consumption. The results of the multiple regression analyses demonstrated that RBP4 level was independently associated with SBP (β=0.427, P<0.001) and DBP (β=0.338, P<0.001). In conclusion, serum RBP4 level was significantly higher and closely associated with BP in prehypertensive Chinese.
视黄醇结合蛋白4（RBP4）已被报道与高血压的发生和发展有关。然而，迄今为止，关于高血压前期血清RBP4水平与血压（BP）之间的相关性数据很少。因此，本研究对中国高血压前期人群的这种关联进行了调查。本研究共纳入160例高血压前期患者（高血压前期组）和160例血压正常者（正常血压组）。根据体重指数（BMI）将受试者分为以下四个亚组：肥胖高血压前期亚组；非肥胖高血压前期亚组；肥胖正常血压亚组；非肥胖正常血压亚组（每组n = 80）。测量人体测量学参数、收缩压（SBP）、舒张压（DBP）和一些生化参数。采用放射免疫分析法评估空腹胰岛素水平。采用酶联免疫吸附测定法测量血清RBP4水平。高血压前期组的血清RBP4水平高于正常血压组（P < 0.001）。此外，肥胖高血压前期亚组的RBP4水平高于非肥胖高血压前期亚组（P = 0.005）。然而，肥胖和非肥胖正常血压亚组之间的RBP4水平没有差异（P = 0.317）。在校正年龄、性别、吸烟状况和饮酒量后，RBP4水平与BMI（r = 0.226，P = 0.001）、SBP（r = 0.468，P < 0.001）和DBP（r = 0.358，P < 0.001）呈正相关。多元回归分析结果表明，RBP4水平与SBP（β = 0.427，P < 0.001）和DBP（β = 0.338，P < 0.001）独立相关。总之，中国高血压前期人群的血清RBP4水平显著升高，且与血压密切相关。
