抗 TNF-α 治疗在炎症性肺疾病中的应用。
Anti-TNFα therapy in inflammatory lung diseases.
机构信息
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
Department of Environmental and Occupational Health, School of Public Health, Rutgers University, Piscataway, NJ, USA.
出版信息
Pharmacol Ther. 2017 Dec;180:90-98. doi: 10.1016/j.pharmthera.2017.06.008. Epub 2017 Jun 19.
Abstract
Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), sarcoidosis, and interstitial pulmonary fibrosis (IPF). TNFα plays multiple roles in disease pathology by inducing an accumulation of inflammatory cells, stimulating the generation of inflammatory mediators, and causing oxidative and nitrosative stress, airway hyperresponsiveness and tissue remodeling. TNFα-targeting biologics, therefore, present a potentially highly efficacious treatment option. This review summarizes current knowledge on the role of TNFα in pulmonary disease pathologies, with a focus on the therapeutic potential of TNFα-targeting agents in treating inflammatory lung diseases.
摘要
肿瘤坏死因子 (TNF) α 水平的升高与许多肺部炎症性疾病有关，包括哮喘、慢性阻塞性肺疾病 (COPD)、急性肺损伤 (ALI)/急性呼吸窘迫综合征 (ARDS)、结节病和间质性肺纤维化 (IPF)。TNFα 通过诱导炎症细胞的积累、刺激炎症介质的产生以及导致氧化和硝化应激、气道高反应性和组织重塑，在疾病发病机制中发挥多种作用。因此，TNFα 靶向生物制剂提供了一种潜在的高效治疗选择。本综述总结了 TNFα 在肺部疾病发病机制中的作用的现有知识，重点介绍了 TNFα 靶向药物在治疗炎症性肺病方面的治疗潜力。
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