Zahed Pasha Yadollah, Vahedi Amin, Zamani Mohammad, Alizadeh-Navaei Reza, Zahed Pasha Ermia
Permanent Member of the Academy of Medical Sciences of Islamic Republic of Iran, Babol University of Medical Sciences, Babol, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Arch Iran Med. 2017 Jun 1;20(6):376-385.
Birth defects are a series of disorders that occur during embryonic life. In Iran, no national situation analysis is available to show the rate of congenital disorders. We aimed to estimate the prevalence of structural birth defects in Iran.
We searched for English studies on PubMed, Scopus and Google Scholar from January 1990 to July 2016. The search for Persian articles was performed in Scientific Information Database and Magiran. Two reviewers assessed the identified articles independently. The relevant studies were selected based on predefined criteria. Data were analyzed using the Comprehensive Meta-Analysis software. Random effect method was used for meta-analysis.
In total, 42 studies were included. The prevalence of congenital anomalies was as follows: orofacial clefts, 1.4 per 1,000 births (95% confidence interval [CI]: 1.2-1.6); neural tube defects, 3.2 per 1,000 births (95% CI: 2.5-4.3); urogenital anomalies, 3.9 per 1,000 births (95% CI: 1.2-12.9); musculoskeletal malformations, 3.3 per 1,000 births (95% CI: 2.3-4.9); cardiovascular anomalies, 3.3 per 1,000 births (95% CI: 2.2-5.1); Down syndrome, 0.9 per 1,000 births (95% CI: 0.7-1.2); gastrointestinal disorders, 1.4 per 1,000 births (95% CI: 0.9-2.1).
Our results show that urogenital disorders are the most prevalent births defects in Iran, followed by musculoskeletal and cardiovascular malformations.
出生缺陷是胚胎期出现的一系列病症。在伊朗，尚无全国性情况分析来表明先天性疾病的发生率。我们旨在估算伊朗结构性出生缺陷的患病率。
我们在1990年1月至2016年7月期间在PubMed、Scopus和谷歌学术上搜索英文研究。在科学信息数据库和Magiran中搜索波斯语文章。两名评审员独立评估所识别的文章。根据预先设定的标准选择相关研究。使用综合荟萃分析软件进行数据分析。荟萃分析采用随机效应方法。
总共纳入42项研究。先天性异常的患病率如下：口面部裂，每1000例出生中有1.4例（95%置信区间[CI]：1.2 - 1.6）；神经管缺陷，每1000例出生中有3.2例（95% CI：2.5 - 4.3）；泌尿生殖系统异常，每1000例出生中有3.9例（95% CI：1.2 - 12.9）；肌肉骨骼畸形，每1000例出生中有3.3例（95% CI：2.3 - 4.9）；心血管异常，每1000例出生中有3.3例（95% CI：2.2 - 5.1）；唐氏综合征，每1000例出生中有0.9例（95% CI：0.7 - 1.2）；胃肠道疾病，每1000例出生中有1.4例（95% CI：0.9 - 2.1）。
我们的结果表明，泌尿生殖系统疾病是伊朗最常见的出生缺陷，其次是肌肉骨骼和心血管畸形。
