Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.
J Infect. 2017 Jun;74 Suppl 1:S114-S119. doi: 10.1016/S0163-4453(17)30201-3.
Whooping cough is a highly contagious, acute respiratory disease, caused by the Gram-negative bacterium Bordetella pertussis (Bp). Despite the introduction and widespread use of vaccines starting in the 1950s pertussis cases continue to be reported, with a significant global impact. The role of specific virulence factors in disease and the immune mechanisms associated with protection following natural infection or vaccination are still not completely understood. The recently-developed baboon model of clinical pertussis provides a valuable tool for the study of pertussis. Baboons infected with B. pertussis exhibit all of the manifestations of human pertussis including paroxysmal coughing, mucus production, leukocytosis and transmission. The establishment of this model provides the opportunity to address unanswered questions about the natural progression of this disease and host responses to infection and vaccination in a very relevant model. In this review, we present an overview of our knowledge of pertussis along with recent advances resulting from use of the baboon model. Remaining questions and future research directions are discussed. We hope that the knowledge gained through use of the baboon model of pertussis and clinical studies will allow the development of more efficacious vaccines, conferring long lasting protection against disease and transmission.
百日咳是一种高度传染性的急性呼吸道疾病，由革兰氏阴性细菌百日咳博德特氏菌（Bp）引起。尽管自 20 世纪 50 年代以来引入并广泛使用了疫苗，但仍有百日咳病例报告，对全球产生了重大影响。特定毒力因子在疾病中的作用以及自然感染或接种疫苗后与保护相关的免疫机制仍不完全清楚。最近开发的临床百日咳狒狒模型为百日咳的研究提供了一种有价值的工具。感染百日咳博德特氏菌的狒狒表现出所有人类百日咳的表现，包括阵发性咳嗽、黏液产生、白细胞增多和传播。该模型的建立为解决有关该疾病自然进展以及宿主对感染和疫苗接种反应的未解决问题提供了机会，是一种非常相关的模型。在这篇综述中，我们概述了我们对百日咳的认识，以及使用狒狒模型取得的最新进展。讨论了尚存的问题和未来的研究方向。我们希望通过使用狒狒模型和临床研究获得的知识将有助于开发更有效的疫苗，从而对疾病和传播提供持久的保护。
