Sasaki Motoharu, Tominaga Masahide, Kamomae Takeshi, Ikushima Hitoshi, Kitaoka Motonori, Bando Ryota, Sakuragawa Kanako, Oita Masataka
Department of Radiological Technology, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.
Department of Therapeutic Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.
Jpn J Radiol. 2017 Sep;35(9):511-525. doi: 10.1007/s11604-017-0661-8. Epub 2017 Jun 24.
The aim of this study was to quantify the effect of multi-leaf collimators (MLCs) with different leaf widths on the planning of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Toward this objective, dose transmission through a high-definition 120-leaf MLC (HD120MLC) and 120-leaf Millennium MLC (M120MLC) was investigated, using it with a test case and clinical case studies. In test case, studies with IMRT and VMAT plans, the difference in MLC leaf width had a limited effect on planning target volumes (PTVs). Organs at risk (OARs) were more affected by a reduction in dose transmission through the MLC than by a reduction in MLC leaf width. The results of the test case studies and clinical case studies were mostly similar. In the latter, the different MLCs had no effect on the PTV regardless of the treatment method; however, the HD120MLC plans achieved dose reductions to OARs similar to or larger than the dose reduction of the M120MLC plans. The similar results of the test case and clinical case studies showed that despite a limitation of the irradiation field size, the HD120MLC plans were superior.
本研究的目的是量化不同叶片宽度的多叶准直器（MLC）对调强放射治疗（IMRT）和容积调强弧形治疗（VMAT）计划的影响。为实现这一目标，使用一个测试案例和临床案例研究，研究了通过高清120叶MLC（HD120MLC）和120叶千禧MLC（M120MLC）的剂量传输。在测试案例中，对IMRT和VMAT计划的研究表明，MLC叶片宽度的差异对计划靶体积（PTV）的影响有限。危及器官（OAR）受MLC剂量传输减少的影响比受MLC叶片宽度减少的影响更大。测试案例研究和临床案例研究的结果大多相似。在后者中，无论治疗方法如何，不同的MLC对PTV均无影响；然而，HD120MLC计划实现的OAR剂量减少与M120MLC计划的剂量减少相似或更大。测试案例和临床案例研究的相似结果表明，尽管照射野大小有限，但HD120MLC计划更具优势。
