Shou Kangquan, Tang Yufu, Chen Hao, Chen Si, Zhang Lei, Zhang Ao, Fan Quli, Yu Aixi, Cheng Zhen
Department of Orthopedics , Zhongnan Hospital of Wuhan University , Wuhan , Hubei 430071 , China . Email:
Molecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email:
Chem Sci. 2018 Feb 6;9(12):3105-3110. doi: 10.1039/c8sc00206a. eCollection 2018 Mar 28.
A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000-1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.
一种基于二酮吡咯并吡咯的半导体聚合物纳米颗粒（PDFT1032）已被开发为一种近红外二区（1000 - 1700纳米）荧光探针。它具有高光稳定性、在809纳米处有良好的吸收峰、223纳米的大斯托克斯位移、出色的生物相容性和极低的毒性。更重要的是，已证明PDFT1032可在近红外二区窗口用于多种重要的生物医学应用，包括在皮下骨肉瘤模型上对肿瘤进行近红外二区光学成像、评估肿瘤的血管栓塞治疗，以及以高空间和时间分辨率进行近红外二区图像引导的原位肿瘤手术和前哨淋巴结活检（SLNB）。总体而言，出色的生物相容性、良好的亲水性以及理想的化学和光学性质，使得半导体聚合物纳米颗粒PDFT1032成为一种极具前景的近红外二区成像探针，具有在临床成像和恶性肿瘤手术治疗中广泛应用的潜力。
