TACC3基因rs798766多态性与膀胱癌风险的关联：基于当前证据的综合分析
Association between the TACC3 rs798766 Polymorphism and Risk of Urinary Bladder Cancer: A Synthesis Based on Current Evidence.
作者信息
Meng Xiang-Yu, Shi Ming-Jun, Chen Jia-Feng, Liao Yi, Hu Bang-Wang, Hireche Ahmed
机构信息
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France.
出版信息
Dis Markers. 2017;2017:7850708. doi: 10.1155/2017/7850708. Epub 2017 Jun 5.
BACKGROUND
A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision.
METHODS
EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. "rs798766" and "urinary bladder cancer" were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated.
RESULTS
We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] OR = 1.27, 95%CI = 1.20-1.33. Subgroup analysis by ethnicity revealed similar results, allelic[T] OR = 1.24, 95%CI = 1.17-1.32 in Caucasian subjects and allelic[T] OR = 1.33, 95%CI = 1.21-1.46 in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians.
CONCLUSION
rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.
背景
已发表的文献表明TACC3基因rs798766多态性与膀胱癌风险之间可能存在关联。我们进行了这项荟萃分析，综合所有相关数据，以总结当前可用的证据，并提供更精确的估计。
方法
检索了EMBASE、PubMed、谷歌学术和万方数据。使用“rs798766”和“膀胱癌”作为检索词。共确定了6项符合条件的研究，其中调查了8194例病例和50165例对照。使用提取的数据进行荟萃分析。还按种族进行了亚组分析。计算了人群归因风险（PAR）。
结果
我们发现rs798766[T]与膀胱癌风险增加之间存在显著关联，等位基因[T]的比值比（OR）=1.27，95%置信区间（CI）=1.20-1.33。按种族进行的亚组分析显示了类似的结果，白种人受试者中等位基因[T]的OR=1.24，95%CI=1.17-1.32，亚洲受试者中等位基因[T]的OR=1.33，95%CI=1.21-1.46。基于合并等位基因OR和对照受试者中风险等位基因频率计算的PAR在总体人群中为4.63%，在亚洲人中为3.92%，在白种人中为4.36%。
结论
rs798766与膀胱癌风险增加相关，且未发现种族差异。
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