Rodríguez Alexander J, Karim Md N, Srikanth Velandai, Ebeling Peter R, Scott David
Bone and Muscle Health Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Prahan, Australia.
Clin Exp Pharmacol Physiol. 2017 Oct;44(10):980-992. doi: 10.1111/1440-1681.12805. Epub 2017 Aug 24.
Muscle loss and arterial stiffness share common risk factors and are commonly seen in the elderly. We aimed to synthesise the existing literature on studies that have examined this association. We searched electronic databases for studies reporting correlations or associations between a measure of muscle tissue and a measure of arterial stiffness. Meta-analysis was conducted using Fisher's Z-transformed r-correlation (r ) values. Pooled weighted r and 95% confidence intervals were calculated in an inverse-variance, random-effects model. Heterogeneity was assessed by the inconsistency index (I ). Study quality was assessed on a checklist using items from validated quality appraisal guidelines. 1195 records identified, 21 satisfied our inclusion criteria totalling 8558 participants with mean age 52±4 years (range 23-74). Most studies reported an inverse relationship between muscle tissue and arterial stiffness. Eight studies had data eligible for meta-analysis. Muscle tissue was inversely associated with pulse wave velocity in healthy individuals [r =-.15 (95% CI -0.24, -0.07); P=.0006; I =85%; n=3577] and in any population [r =-.18 (-0.26, -0.10); P<.0001; I =81%; n=3930]. In a leave-one-out sensitivity analysis, the results remained unchanged. Lower muscle tissue was associated with arterial stiffness. Studies were limited by cross-sectional design. Cardiovascular risk monitoring may be strengthened by screening for low muscle mass and maintaining muscle mass may be a primary prevention strategy.
肌肉流失和动脉僵硬度有共同的风险因素，且在老年人中很常见。我们旨在综合现有关于研究这一关联的文献。我们在电子数据库中搜索了报告肌肉组织测量值与动脉僵硬度测量值之间相关性或关联性的研究。使用费舍尔Z变换r相关（r）值进行荟萃分析。在逆方差随机效应模型中计算合并加权r和95%置信区间。通过不一致指数（I）评估异质性。使用经过验证的质量评估指南中的项目，根据一份清单评估研究质量。共识别出1195条记录，21项符合我们的纳入标准，共有8558名参与者，平均年龄52±4岁（范围23 - 74岁）。大多数研究报告肌肉组织与动脉僵硬度之间呈负相关。八项研究有可用于荟萃分析的数据。在健康个体中，肌肉组织与脉搏波速度呈负相关[r = -0.15（95%CI -0.24，-0.07）；P = 0.0006；I = 85%；n = 3577]，在任何人群中也是如此[r = -0.18（-0.26，-0.10）；P < 0.0001；I = 81%；n = 3930]。在留一法敏感性分析中，结果保持不变。较低的肌肉组织与动脉僵硬度相关。研究受横断面设计的限制。通过筛查低肌肉量可能会加强心血管风险监测，维持肌肉量可能是一种一级预防策略。
