Morisset J, Génik P
Regul Pept. 1983 Jan;5(2):111-23. doi: 10.1016/0167-0115(83)90119-2.
We studied the effects of acute and chronic administration of secretin and caerulein, alone and in combination, on RNA and protein synthesis in the duodenum and oxyntic gland area as well as content of DNA, RNA and protein in rats. Secretin, 100 micrograms . kg-1, three times a day for 5 days, was associated with duodenal hypertrophy after the first 24 h of treatment and hyperplasia at the end of days 2 and 4; hypertrophy of the oxyntic gland area was observed only at 4 h after the first injection. Caerulein, 1 microgram . kg-1, also promoted duodenal hyperplasia after 2 and 4 days of treatment. The oxyntic gland area showed hypertrophy only at 4 h after the second injection of caerulein. These data indicate that both hormones can induce duodenal hyperplasia, probably by an amplification of the normal renewal cycle of the epithelial cells. They also demonstrated that growth of the oxyntic gland area is not promoted by these two peptides at the doses studied.
我们研究了单独及联合急性和慢性给予促胰液素和蛙皮素对大鼠十二指肠和泌酸腺区RNA和蛋白质合成以及DNA、RNA和蛋白质含量的影响。促胰液素，100微克·千克⁻¹，每天3次，共5天，在治疗的最初24小时后与十二指肠肥大有关，在第2天和第4天结束时出现增生；仅在首次注射后4小时观察到泌酸腺区肥大。蛙皮素，1微克·千克⁻¹，在治疗2天和4天后也促进十二指肠增生。仅在第二次注射蛙皮素后4小时，泌酸腺区出现肥大。这些数据表明，这两种激素都可能通过放大上皮细胞的正常更新周期来诱导十二指肠增生。他们还证明，在所研究的剂量下，这两种肽不会促进泌酸腺区的生长。
