Montespan Charlotte, Wiethoff Christopher M, Wodrich Harald
CNRS UMR 5234, Microbiologie Fondamentale et Pathogénicité, Université de Bordeaux, Bordeaux, France.
Biologics ADME, Drug Disposition Labs, Lilly Corporate Center, Indianapolis, Indiana, USA.
J Virol. 2017 Aug 24;91(18). doi: 10.1128/JVI.00581-17. Print 2017 Sep 15.
Autophagy is an essential metabolic program that is also used for clearing intracellular pathogens. This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented for viral infections. Here we highlight our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells. Our study revealed how adenoviruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promote endosomal escape and nuclear trafficking.
自噬是一种重要的代谢程序，也用于清除细胞内病原体。这种机制，也称为选择性自噬，对于侵袭性细菌已得到充分表征，但对于病毒感染的记录仍然很少。在这里，我们重点介绍我们最近的工作，该工作表明溶酶体腺病毒在进入细胞时会触发自噬。我们的研究揭示了腺病毒如何利用衣壳相关的小PPxY肽基序来操纵自噬机制，以防止自噬降解并促进内体逃逸和核运输。
