Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, Paris Cedex 05, 75205, France.
Dipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, Lecce, 73100, Italy.
Small. 2017 Aug;13(31). doi: 10.1002/smll.201701274. Epub 2017 Jun 29.
In order to provide insight into how anisotropic nano-objects interact with living cell membranes, and possibly self-assemble, magnetic nanorods with an average size of around 100 nm × 1 µm are designed by assembling iron oxide nanocubes within a polymeric matrix under a magnetic field. The nano-bio interface at the cell membrane under the influence of a rotating magnetic field is then explored. A complex structuration of the nanorods intertwined with the membranes is observed. Unexpectedly, after a magnetic rotating stimulation, the resulting macrorods are able to rotate freely for multiple rotations, revealing the creation of a biomagnetic torsion pendulum.
为了深入了解各向异性纳米物体与活细胞膜的相互作用方式，以及可能的自组装方式，我们通过在磁场中组装氧化铁纳米立方体，在聚合物基质中设计出平均尺寸约为 100nm×1μm 的磁性纳米棒。然后研究了在旋转磁场影响下细胞膜上的纳米-生物界面。观察到纳米棒与细胞膜交织在一起的复杂结构。出乎意料的是，经过磁场旋转刺激后，生成的宏观棒能够自由旋转多次，揭示了生物磁扭转摆的产生。
