Taylor G, Stott E J, Hayle A J
J Gen Virol. 1985 Dec;66 ( Pt 12):2533-8. doi: 10.1099/0022-1317-66-12-2533.
Mice infected with respiratory syncytial virus (RSV) developed cytotoxic lymphocytes in the lungs, which lysed RSV-infected, but not uninfected cells. Cytotoxic activity was greatest 7 to 9 days after infection, was virus-specific, MHC-restricted and abolished by treatment of lymphocytes with anti-Thy 1.2 or with anti-Lyt 2.2 sera and complement. There was a close temporal relationship between the appearance of these cytotoxic lymphocytes in the lung and clearance of virus. In contrast, RSV persisted in the lungs of athymic (nude) mice and such animals failed to develop RSV-specific cytotoxic lymphocytes. Thus, cytotoxic T-cells may have an important role in recovery from RSV infection.
感染呼吸道合胞病毒（RSV）的小鼠肺部产生了细胞毒性淋巴细胞，这些细胞毒性淋巴细胞可裂解被RSV感染的细胞，但不会裂解未感染的细胞。细胞毒性活性在感染后7至9天最强，具有病毒特异性、MHC限制性，并且用抗Thy 1.2或抗Lyt 2.2血清及补体处理淋巴细胞可消除这种活性。这些细胞毒性淋巴细胞在肺部出现与病毒清除之间存在密切的时间关系。相比之下，RSV在无胸腺（裸）小鼠的肺部持续存在，且此类动物未能产生RSV特异性细胞毒性淋巴细胞。因此，细胞毒性T细胞可能在从RSV感染中恢复过程中发挥重要作用。
