Department of Biochemistry and Molecular Biology and Center for Molecular Medicine, University of Georgia, 500 D.W. Brooks Drive, Athens, GA 30602, USA.
Department of Biochemistry and Molecular Biology and Center for Molecular Medicine, University of Georgia, 500 D.W. Brooks Drive, Athens, GA 30602, USA.
Curr Opin Genet Dev. 2017 Oct;46:44-49. doi: 10.1016/j.gde.2017.06.008. Epub 2017 Jul 4.
Cell fate decisions are closely linked to changes in metabolic activity. Over recent years this connection has been implicated in mechanisms underpinning embryonic development, reprogramming and disease pathogenesis. In addition to being important for supporting the energy demands of different cell types, metabolic switching from aerobic glycolysis to oxidative phosphorylation plays a critical role in controlling biosynthetic processes, intracellular redox state, epigenetic status and reactive oxygen species levels. These processes extend beyond ATP synthesis by impacting cell proliferation, differentiation, enzymatic activity, ageing and genomic integrity. This review will focus on how metabolic switching impacts decisions made by multipotent cells and discusses mechanisms by which this occurs.
细胞命运决定与代谢活性的变化密切相关。近年来，这种联系已被牵涉到胚胎发育、重编程和疾病发病机制的机制中。除了支持不同细胞类型的能量需求外，代谢从有氧糖酵解向氧化磷酸化的转变对于控制生物合成过程、细胞内氧化还原状态、表观遗传状态和活性氧水平也起着至关重要的作用。这些过程通过影响细胞增殖、分化、酶活性、衰老和基因组完整性，超越了 ATP 合成的作用。本文综述了代谢转换如何影响多能细胞做出的决策，并讨论了发生这种情况的机制。
