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Serum Cystatin C as a Biomarker for Early Diabetic Kidney Disease and Dyslipidemia in Young Type 1 Diabetes Patients.血清胱抑素 C 作为年轻 1 型糖尿病患者早期糖尿病肾病和血脂异常的生物标志物。
Medicina (Kaunas). 2022 Feb 1;58(2):218. doi: 10.3390/medicina58020218.
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3
Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus.新诊断2型糖尿病患者血清视黄醇结合蛋白-4、胱抑素C、同型半胱氨酸及高敏C反应蛋白水平的相关性
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本文引用的文献

1
US Renal Data System 2015 Annual Data Report: Epidemiology of Kidney Disease in the United States.《美国肾脏数据系统2015年年报：美国肾脏疾病流行病学》
Am J Kidney Dis. 2016 Mar;67(3 Suppl 1):Svii, S1-305. doi: 10.1053/j.ajkd.2015.12.014.
2
3. Foundations of Care and Comprehensive Medical Evaluation.3. 护理基础与综合医学评估。
Diabetes Care. 2016 Jan;39 Suppl 1:S23-35. doi: 10.2337/dc16-S006.
3
Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure.健康儿童和青少年的胱抑素C水平：年龄、性别、体重指数和血压的影响
Clin Biochem. 2016 Jan;49(1-2):150-3. doi: 10.1016/j.clinbiochem.2015.10.012. Epub 2015 Oct 24.
4
Performance in Measurement of Serum Cystatin C by Laboratories Participating in the College of American Pathologists 2014 CYS Survey.参与美国病理学家学会2014年胱抑素C检测调查的实验室在血清胱抑素C检测中的表现。
Arch Pathol Lab Med. 2015 Jul;139(7):888-93. doi: 10.5858/arpa.2014-0427-CP. Epub 2015 Apr 17.
5
A practical method to measure GFR in people with type 1 diabetes.一种测量1型糖尿病患者肾小球滤过率的实用方法。
J Diabetes Complications. 2014 Sep-Oct;28(5):667-73. doi: 10.1016/j.jdiacomp.2014.06.001. Epub 2014 Jun 9.
6
Glomerular filtration rate estimation using cystatin C alone or combined with creatinine as a confirmatory test.单独使用胱抑素 C 或联合使用肌酐作为确证试验估算肾小球滤过率。
Nephrol Dial Transplant. 2014 Jun;29(6):1195-203. doi: 10.1093/ndt/gft509. Epub 2014 Jan 20.
7
Longitudinal changes in estimated and measured GFR in type 1 diabetes.1 型糖尿病患者估算肾小球滤过率和实测肾小球滤过率的纵向变化。
J Am Soc Nephrol. 2014 Apr;25(4):810-8. doi: 10.1681/ASN.2013050557. Epub 2013 Dec 5.
8
Earlier onset of complications in youth with type 2 diabetes. 2 型糖尿病青年患者并发症的发病年龄更早。
Diabetes Care. 2014 Feb;37(2):436-43. doi: 10.2337/dc13-0954. Epub 2013 Oct 15.
9
Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial.2 型糖尿病青少年中高血压和肾病的迅速增加： TODAY 临床试验。
Diabetes Care. 2013 Jun;36(6):1735-41. doi: 10.2337/dc12-2420.
10
Within-person variability in kidney measures.个体内肾脏指标的变异性。
Am J Kidney Dis. 2013 May;61(5):716-22. doi: 10.1053/j.ajkd.2012.11.048. Epub 2013 Jan 20.

青少年糖尿病患者的血清胱抑素C：青少年糖尿病研究（SEARCH）

Serum cystatin C in youth with diabetes: The SEARCH for diabetes in youth study.

作者信息

Kanakatti Shankar Roopa, Dolan Lawrence M, Isom Scott, Saydah Sharon, Maahs David M, Dabelea Dana, Reynolds Kristi, Hirsch Irl B, Rodriguez Beatriz L, Mayer-Davis Elizabeth J, Marcovina Santica, D'Agostino Ralph, Mauer Michael, Mottl Amy K

机构信息

Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

出版信息

Diabetes Res Clin Pract. 2017 Aug;130:258-265. doi: 10.1016/j.diabres.2017.06.010. Epub 2017 Jun 12.

DOI:10.1016/j.diabres.2017.06.010
PMID:28666182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5575920/
Abstract

AIMS

We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D).

METHODS

Youth (ages 12-19years) without diabetes (N=544) were ascertained from the NHANES Study 2000-2002 and those with T1D (N=977) and T2D (N=168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI.

RESULTS

Adjusted cystatin C concentrations were statistically higher in NHANES (0.85mg/L) than in either the T1D (0.75mg/L) or T2D (0.70mg/L) SEARCH groups (P<0.0001). Fasting glucose was inversely related to cystatin C only in T1D (P<0.001) and BMI positively associated only in T2D (P<0.01) while HbA1c was inversely associated in both groups.

CONCLUSIONS

Cystatin C concentrations are statistically higher in youth without diabetes compared to T1D or T2D, however the clinical relevance of this difference is quite small, especially in T1D. In youth with diabetes, cystatin C varies with BMI and acute and chronic glycemic control, however their effects may be different according to diabetes type.

摘要

目的

我们比较了患有和未患糖尿病的青少年的胱抑素C水平，并确定了1型糖尿病（T1D）和2型糖尿病（T2D）青少年中与胱抑素C相关的因素。

方法

从2000 - 2002年美国国家健康与营养检查调查（NHANES）中确定了544名无糖尿病的青少年（年龄12 - 19岁），并从青少年糖尿病研究（SEARCH）中确定了977名T1D和168名T2D青少年。比较了三组中胱抑素C浓度的校正均值。接下来，我们在T1D和T2D的SEARCH样本中进行多变量分析，以确定胱抑素C与种族、性别、年龄、糖尿病病程、糖化血红蛋白（HbA1c）、空腹血糖和体重指数（BMI）之间的关联。

结果

NHANES组（0.85mg/L）的校正胱抑素C浓度在统计学上高于T1D组（0.75mg/L）和T2D组（0.70mg/L）的SEARCH组（P<0.0001）。仅在T1D中空腹血糖与胱抑素C呈负相关（P<0.001），仅在T2D中BMI与胱抑素C呈正相关（P<0.01），而HbA1c在两组中均呈负相关。

结论

与T1D或T2D相比，无糖尿病的青少年中胱抑素C浓度在统计学上更高，然而这种差异的临床相关性相当小，尤其是在T1D中。在患有糖尿病的青少年中，胱抑素C随BMI以及急性和慢性血糖控制而变化，然而其影响可能因糖尿病类型而异。