Rogal Julia, Probst Christopher, Loskill Peter
Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstrasse 12, 70569 Stuttgart, Germany.
Future Sci OA. 2017 Mar 13;3(2):FSO180. doi: 10.4155/fsoa-2016-0092. eCollection 2017 Jun.
Multi-organ platforms have an enormous potential to lead to a paradigm shift in a multitude of research domains including drug development, toxicological screening, personalized medicine as well as disease modeling. Integrating multiple organ-tissues into one microfluidic circulation merges the advantages of cell lines (human genetic background) and animal models (complex physiology) and enables the creation of more -like models. In recent years, a variety of design concepts for multi-organ platforms have been introduced, categorizable into static, semistatic and flexible systems. The most promising approach seems to be flexible interconnection of single-organ platforms to application-specific multi-organ systems. This perspective elucidates the concept of 'mix-and-match' toolboxes and discusses the numerous advantages compared with static/semistatic platforms as well as remaining challenges.
多器官平台在包括药物开发、毒理学筛选、个性化医疗以及疾病建模等众多研究领域引发范式转变方面具有巨大潜力。将多个器官组织整合到一个微流体循环中，融合了细胞系（人类遗传背景）和动物模型（复杂生理学）的优势，能够创建更具生理相似性的模型。近年来，已引入了多种多器官平台的设计概念，可分为静态、半静态和灵活系统。最具前景的方法似乎是将单器官平台灵活互连为特定应用的多器官系统。本观点阐述了“混合搭配”工具箱的概念，并讨论了与静态/半静态平台相比的众多优势以及尚存的挑战。
