Aryal Sajesan, Bisht Gunjan
Department of Biotechnology, School of Science, Kathmandu University, Dhulikhel 45200, Nepal.
Department of Chemical Science and Engineering, Kathmandu University, Dhulikhel 45200, Nepal.
Biomedicines. 2017 Jul 1;5(3):38. doi: 10.3390/biomedicines5030038.
Application of Gold nanoparticles and Cold Atmospheric plasma as a targeted therapeutic adjunct has been widely investigated separately in cancer therapy. Gold nanoparticles, with their biocompatibility, lower cytotoxicity and superior efficacy, are becoming substantially more significant in modern cancer therapy. Likewise, cold atmospheric plasma, with rich reactive species including reactive oxygen species (ROS) and reactive nitrogen species (RNS), is being explored to selectively target and kill cancer cells, making them a promising anticancer agent. Recent scientific studies have shown that there is a potential synergy between these two aspects. Induction of apoptosis/necrosis due to oxidative stress may be a probable mechanism of their cytotoxic effect. The synergetic effect of the two therapeutic approaches could be tantamount to maximized targeted efficacy on the treatment of diseases like cancer.
金纳米颗粒和冷大气等离子体作为靶向治疗辅助手段在癌症治疗中已分别得到广泛研究。金纳米颗粒具有生物相容性、较低的细胞毒性和卓越的疗效，在现代癌症治疗中变得越来越重要。同样，冷大气等离子体含有包括活性氧（ROS）和活性氮（RNS）在内的丰富活性物质，正被探索用于选择性地靶向和杀死癌细胞，使其成为一种有前景的抗癌剂。最近的科学研究表明，这两个方面之间存在潜在的协同作用。氧化应激诱导的细胞凋亡/坏死可能是其细胞毒性作用的一种可能机制。这两种治疗方法的协同效应可能等同于在治疗癌症等疾病时最大化靶向疗效。
